Usefulness of 2-[18F]-fluoro-2-deoxy-D-glucose-Positron Emission Tomography/Computed Tomography for Staging and Evaluation of Treatment Response in IgG4-Related Disease: A Retrospective Multicenter Study

被引：145

作者：

Ebbo, Mikael ^{[1
]}

Grados, Aurelie ^{[1
]}

Guedj, Eric ^{[2
]}

Gobert, Delphine ^{[3
]}

Colavolpe, Cecile ^{[2
]}

Zaidan, Mohamad ^{[4
]}

Masseau, Agathe ^{[5
]}

Bernard, Fanny ^{[6
]}

Berthelot, Jean-Marie ^{[5
]}

Morel, Nathalie ^{[7
]}

Lifermann, Francois ^{[8
]}

Palat, Sylvain ^{[9
]}

Haroche, Julien ^{[7
]}

Mariette, Xavier ^{[10
]}

Godeau, Bertrand ^{[11
]}

Bernit, Emmanuelle ^{[1
]}

Costedoat-Chalumeau, Nathalie ^{[7
]}

Papo, Thomas ^{[3
]}

Hamidou, Mohamed ^{[5
]}

Harle, Jean-Robert ^{[1
]}

Schleinitz, Nicolas ^{[1
]}

机构：

[1] Aix Marseille Univ, Ctr Hosp Univ Concept, AP HM, Marseille, France

[2] Aix Marseille Univ, Hop Enfants La Timone, AP HM, CERIMED, Marseille, France

[3] Univ Paris Diderot, Hop Bichat Claude Bernard, AP HP, Paris, France

[4] Univ Paris 05, Hop Necker Enfants Malad, AP HP, Paris, France

[5] Ctr Hosp Univ Hotel Dieu, Nantes, France

[6] Hop Nord Marseille, AP HM, Marseille, France

[7] Univ Paris 06, Hop La Pitie Salpetriere, AP HP, Paris, France

[8] Hop Dax, Dax, France

[9] Ctr Hosp Univ Dupuytren, Limoges, France

[10] Univ Paris 11, Hop Bicetre, AP HP, Le Kremlin Bicetre, France

[11] Univ Paris 12, Hop Henri Mondor, AP HP, F-94010 Creteil, France

来源：

ARTHRITIS CARE & RESEARCH | 2014年 / 66卷 / 01期

关键词：

AUTOIMMUNE PANCREATITIS; FDG-PET; SERUM IGG4; DIAGNOSIS; DIFFERENTIATION; ACCUMULATION; FIBROSIS; FEATURES; UTILITY; TYPE-1;

D O I：

10.1002/acr.22058

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

ObjectiveTo evaluate the usefulness of 2-[F-18]-fluoro-2-deoxy-d-glucose-positron emission tomography/computed tomography (FDG-PET/CT) in IgG4-related disease (IgG4-RD) for the staging of the disease and the followup under treatment. MethodsAll patients included in the French IgG4-RD registry who underwent 1 FDG-PET/CT scan were included in the study. Clinical, biologic, pathologic, radiologic, and FDG-PET/CT qualitative and quantitative findings were retrospectively collected and analyzed. ResultsTwenty-one patients were included in the study and 46 FDG-PET/CT examinations were evaluated. At either diagnosis or relapse, all evaluated patients presented abnormal F-18-FDG uptake in typical IgG4-RD localizations. In most cases, FDG-PET/CT was more sensitive than conventional imaging to detect organ involvement, especially in arteries, salivary glands, and lymph nodes. In few cases (small-sized lesions and brain or kidney contiguous lesions), false-negative results were noted. Evaluation before and after treatment showed in most cases a good correlation of FDG-PET/CT results with treatment response and disease activity. ConclusionThis large retrospective study shows that FDG-PET/CT imaging is useful for the staging of IgG4-RD. Moreover, FDG-PET/CT is useful to assess the response to treatment during followup.

引用

页码：86 / 96

页数：11

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