Analogues of Marine Pyrroloiminoquinone Alkaloids: Synthesis and Antitumor Properties

被引:19
作者
Delfourne, Evelyne [1 ]
机构
[1] Univ Toulouse 3, CNRS, Lab Synth & Physicochim Mol Interet Biol, UMR 5068, F-31062 Toulouse 9, France
关键词
Pyrroloiminoquinone; makaluvamine; isobatzelline; tsitsikammamine; wakayin;
D O I
10.2174/187152008786847710
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Marine organisms provide a valuable source for natural products. In recent years, iminoquinone alkaloids including makaluvamines, isobatzellines, tsitsikammamines and wakayin, have emerged as an essential class of marine metabolites due to their prominent biological activities and unusual ring structures. This review focuses on synthesis and antitumor evaluation of analogues of these products.
引用
收藏
页码:910 / 916
页数:7
相关论文
共 52 条
[1]  
Alvarez M, 1999, EUR J ORG CHEM, V1999, P1173
[2]   Pyrroloiminoquinone and related metabolites from marine sponges [J].
Antunes, EM ;
Copp, BR ;
Davies-Coleman, MT ;
Samaai, T .
NATURAL PRODUCT REPORTS, 2005, 22 (01) :62-72
[3]   Cytotoxic pyrroloiminoquinones from four new species of south African latrunculid sponges [J].
Antunes, EM ;
Beukes, DR ;
Kelly, M ;
Samaai, T ;
Barrows, LR ;
Marshall, KM ;
Sincich, C ;
Davies-Coleman, MT .
JOURNAL OF NATURAL PRODUCTS, 2004, 67 (08) :1268-1276
[4]   A biomimetic approach to the discorhabdin alkaloids: Total syntheses of discorhabdins C and E and dethiadiscorhabdin D [J].
Aubart, KM ;
Heathcock, CH .
JOURNAL OF ORGANIC CHEMISTRY, 1999, 64 (01) :16-22
[5]   Synthesis of a bis-pyrrolo-quinone structure analogue to wakayin [J].
Barret, R ;
Roue, N .
TETRAHEDRON LETTERS, 1999, 40 (20) :3889-3890
[6]  
BARROWS LR, 1993, ANTI-CANCER DRUG DES, V8, P333
[7]   Synthesis and antiproliferative evaluation of 7-aminosubstituted pyrroloiminoquinone derivatives [J].
Bénéteau, V ;
Pierré, A ;
Pfeiffer, B ;
Renard, P ;
Besson, T .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (19) :2231-2234
[8]   Synthesis of novel pentacyclic pyrrolothiazolobenzoquinolinones, analogs of natural marine alkaloids [J].
Bénéteau, V ;
Besson, T .
TETRAHEDRON LETTERS, 2001, 42 (14) :2673-2676
[9]   MAKALUVAMINE-G, A CYTOTOXIC PIGMENT FROM AN INDONESIAN SPONGE HISTODERMELLA SP [J].
CARNEY, JR ;
SCHEUER, PJ ;
KELLYBORGES, M .
TETRAHEDRON, 1993, 49 (38) :8483-8486
[10]   Makaluvamine P, a new cytotoxic pyrroloiminoquinone from Zyzzya cf. fuliginosa [J].
Casapullo, A ;
Cutignano, A ;
Bruno, I ;
Bifulco, G ;
Debitus, C ;
Gomez-Paloma, L ;
Riccio, R .
JOURNAL OF NATURAL PRODUCTS, 2001, 64 (10) :1354-1356