(-)-Epigallocatechin-3-gallate Potentiates the Cytotoxicity Induced by Benzyl Isothiocyanate and Hydrogen Peroxide in Human Jurkat T Lymphocytes

被引：9
|
作者：
Wu, Haitao [1 ,2 ]
Yokoyama, Tomoko [1 ]
Zhu, Beiwei [2 ]
Shimoishi, Yasuaki [1 ]
Murata, Yoshiyuki [1 ]
Nakamura, Yoshimasa [1 ]
机构：
[1] Okayama Univ, Grad Sch Nat Sci & Technol, Okayama 7008530, Japan
[2] Dalian Polytech Univ, Coll Bio & Food Technol, Dalian 116034, Peoples R China
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2008年 / 72卷 / 11期
关键词：
(-)-epigallocatechin-3-gallate (EGCG); extracellular signal-regulated protein kinase (ERK); C-jun N-terminal kinase (JNK); apoptosis; Jurkat cells;
D O I：
10.1271/bbb.80422
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
(-)-Epigallocatechin-3-gallate (EGCG)-induced apoptosis was along both the extracellular signal-regulated protein kinase (ERK) and c-jun N-terminal kinase (JNK) pathways in Jurkat cells. Co-treatment with EGCG potentiated the cytotoxicity induced by benzyl isothiocyanate (BITC) and H2O2, both being inhibited by ERK and JNK inhibitors. These results suggest the significant role of mitogen-activated protein kinase (MAPK) signaling in the apoptosis induction regulated by EGCG alone and in combination.
引用
收藏
页码：3034 / 3037
页数：4
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