Host resistance to infection - genetic control of lipopolysaccharide responsiveness by TOLL-like receptor genes

被引：78
作者：
Qureshi, ST [1 ]
Gros, P
Malo, D
机构：
[1] McGill Univ, Dept Med, Montreal, PQ H3G 1Y6, Canada
[2] McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada
[3] McGill Univ, Dept Human Genet, Montreal, PQ H3G 1Y6, Canada
[4] Montreal Gen Hosp, Ctr Study Host Resistance, Montreal, PQ H3G 1A4, Canada
来源：
TRENDS IN GENETICS | 1999年 / 15卷 / 08期
关键词：
D O I：
10.1016/S0168-9525(99)01782-5
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Gram-negative bacterial lipopolysaccharide evokes a protective inflammatory response in the normal host. Through genetic analysis of mutant mice, the gene encoding TOLL-like receptor 4 (Tlr4) was recently identified as a critical component of this host defense mechanism. Tlr4 is a member of an ancient gene family that regulates antimicrobial host defense in plants, invertebrates and mammals.
引用
收藏
页码：291 / 294
页数：4
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