Recent highlights in anti-protozoan drug development and resistance research

被引：17

作者：

Buckner, Frederick S. ^{[1
]}

Waters, Norman C. ^{[2
]}

Avery, Vicky M. ^{[3
]}

机构：

[1] Univ Washington, Dept Med, Seattle, WA 98195 USA

[2] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA

[3] Griffith Univ, Nathan, Qld 4111, Australia

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE | 2012年 / 2卷

关键词：

Antiparasitic drug discovery; Drug resistance; Malaria; Protozoa; MALARIA;

D O I：

10.1016/j.ijpddr.2012.05.002

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

This article summarizes the highlights of research presented in January, 2012, at the Keystone Symposium on "Drug Discovery for Protozoan Parasites'' held in Santa Fe, New Mexico. This symposium which convenes approximately every 2 years provides a forum for leading investigators around the world to present data covering basic sciences to clinical trials relating to anti-protozoan drug development and drug resistance. Many talks focused on malaria, but other protozoan diseases receiving attention included African sleeping sickness, Chagas disease, leishmaniasis, cryptosporidiosis, and amoebiasis. The new research, most of it unpublished, provided insights into the latest developments in the field. (C) 2012 Australian Society for Parasitology Published by Elsevier Ltd. All rights reserved.

引用

页码：230 / 235

页数：6

共 6 条

[1] Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria [J].

Charman, Susan A. ;

Arbe-Barnes, Sarah ;

Bathurst, Ian C. ;

Brun, Reto ;

Campbell, Michael ;

Charman, William N. ;

Chiu, Francis C. K. ;

Chollet, Jacques ;

Craft, J. Carl ;

Creek, Darren J. ;

Dong, Yuxiang ;

Matile, Hugues ;

Maurer, Melanie ;

Morizzi, Julia ;

Nguyen, Tien ;

Papastogiannidis, Petros ;

Scheurer, Christian ;

Shackleford, David M. ;

Sriraghavan, Kamaraj ;

Stingelin, Lukas ;

Tang, Yuanqing ;

Urwyler, Heinrich ;

Wang, Xiaofang ;

White, Karen L. ;

Wittlin, Sergio ;

Zhou, Lin ;

Vennerstrom, Jonathan L. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (11) :4400-4405

[2] Mefloquine induces dose-related neurological effects in a rat model [J].

Dow, G ;

Bauman, R ;

Caridha, D ;

Cabezas, M ;

Du, F ;

Gomez-Lobo, R ;

Park, M ;

Smith, K ;

Cannard, K .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (03) :1045-1053

[3]

Meshnick S R, 1998, Med Trop (Mars), V58, P13

[4] Structure-Activity Relationships of 4-Position Diamine Quinoline Methanols as Intermittent Preventative Treatment (IPT) against Plasmodium falciparum [J].

Milner, Erin ;

Gardner, Sean ;

Moon, Jay ;

Grauer, Kristina ;

Auschwitz, Jennifer ;

Bathurst, Ian ;

Caridha, Diana ;

Gerena, Lucia ;

Gettayacamin, Montip ;

Johnson, Jacob ;

Kozar, Michael ;

Lee, Patricia ;

Leed, Susan ;

Li, Qigui ;

McCalmont, William ;

Melendez, Victor ;

Roncal, Norma ;

Sciotti, Richard ;

Smith, Bryan ;

Sousa, Jason ;

Tungtaeng, Anchalee ;

Wipf, Peter ;

Dow, Geoffrey .

JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (18) :6277-6285

[5] Drug-resistant malaria: Molecular mechanisms and implications for public health [J].

Petersen, Ines ;

Eastman, Richard ;

Lanzer, Michael .

FEBS LETTERS, 2011, 585 (11) :1551-1562

[6] Spiroindolones, a Potent Compound Class for the Treatment of Malaria [J].

Rottmann, Matthias ;

McNamara, Case ;

Yeung, Bryan K. S. ;

Lee, Marcus C. S. ;

Zou, Bin ;

Russell, Bruce ;

Seitz, Patrick ;

Plouffe, David M. ;

Dharia, Neekesh V. ;

Tan, Jocelyn ;

Cohen, Steven B. ;

Spencer, Kathryn R. ;

Gonzalez-Paez, Gonzalo E. ;

Lakshminarayana, Suresh B. ;

Goh, Anne ;

Suwanarusk, Rossarin ;

Jegla, Timothy ;

Schmitt, Esther K. ;

Beck, Hans-Peter ;

Brun, Reto ;

Nosten, Francois ;

Renia, Laurent ;

Dartois, Veronique ;

Keller, Thomas H. ;

Fidock, David A. ;

Winzeler, Elizabeth A. ;

Diagana, Thierry T. .

SCIENCE, 2010, 329 (5996) :1175-1180

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