Epigenetics: Concepts and relevance to IBD pathogenesis

被引：42

作者：

Scarpa, Melania ^{[1
,2
]}

Stylianou, Eleni ^{[1
,3
]}

机构：

[1] Cleveland Clin Fdn, Lerner Res Inst, Dept Pathobiol, Cleveland, OH 44195 USA

[2] Univ Padua, IRCCS, IOV, Padua, Italy

[3] Cleveland Clin Fdn, Inst Digest Dis, Dept Gastroenterol & Hepatol, Cleveland, OH 44195 USA

来源：

INFLAMMATORY BOWEL DISEASES | 2012年 / 18卷 / 10期

关键词：

Chromatin; Epigenetics; Gene transcription; Inflammatory bowel disease; Inflammation; HISTONE DEACETYLASE INHIBITOR; SUBEROYLANILIDE HYDROXAMIC ACID; CPG ISLAND HYPERMETHYLATION; HEPATIC STELLATE CELLS; GENE-SPECIFIC CONTROL; DNA METHYLATION; CHROMATIN MODIFICATIONS; EXPERIMENTAL COLITIS; INDUCED ARTHRITIS; TRICHOSTATIN-A;

D O I：

10.1002/ibd.22934

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The purpose of this review is to introduce the exciting field of epigenetics and to describe how it could explain the mechanisms by which environmental changes induce pathological gene expression and determine cell phenotype and function in IBD. We outline how epigenetics research in the context of a variety of clinical conditions, but mainly in cancer, has begun to define the role of multiple combinations of modifications to chromatin, diverse families of enzymes, and non-coding RNAs in determining transcriptional outcomes. These findings are applicable to understanding the context-specific events that underlie the expression of genes in diseases like IBD and have the potential to reveal new targets for improved IBD therapy. The current status of epigenetics-based therapies is also summarized. (Inflamm Bowel Dis 2012)

引用

页码：1982 / 1996

页数：15

共 139 条

[1] Ordered recruitment of chromatin modifying and general transcription factors to the IFN-β promoter [J].