Regulation of bacterial gene expression by riboswitches

被引：540
|
作者：
Winkler, WC [1 ]
Breaker, RR
机构：
[1] Univ Texas, SW Med Ctr, Dept Biochem, Dallas, TX 75390 USA
[2] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA
来源：
ANNUAL REVIEW OF MICROBIOLOGY | 2005年 / 59卷
关键词：
aptamer; RNA switch; ribozyme; transcription attenuation; translation initiation;
D O I：
10.1146/annurev.micro.59.030804.121336
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Riboswitches are structured domains that usually reside in the non-coding regions of mRNAs, where they bind metabolites and control gene expression. Like their protein counterparts, these RNA gene control elements form highly specific binding pockets for the target metabolite and undergo allosteric changes in structure. Numerous classes of riboswitches are present in bacteria and they comprise a common and robust metabolite-sensing system.
引用
收藏
页码：487 / 517
页数：31
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