Regulation of bacterial gene expression by riboswitches

被引：544
作者：
Winkler, WC [1 ]
Breaker, RR
机构：
[1] Univ Texas, SW Med Ctr, Dept Biochem, Dallas, TX 75390 USA
[2] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA
来源：
ANNUAL REVIEW OF MICROBIOLOGY | 2005年 / 59卷
关键词：
aptamer; RNA switch; ribozyme; transcription attenuation; translation initiation;
D O I：
10.1146/annurev.micro.59.030804.121336
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Riboswitches are structured domains that usually reside in the non-coding regions of mRNAs, where they bind metabolites and control gene expression. Like their protein counterparts, these RNA gene control elements form highly specific binding pockets for the target metabolite and undergo allosteric changes in structure. Numerous classes of riboswitches are present in bacteria and they comprise a common and robust metabolite-sensing system.
引用
收藏
页码：487 / 517
页数：31
相关论文
共 111 条
[1]   ALTERNATIVE MESSENGER-RNA STRUCTURES OF THE CIII-GENE OF BACTERIOPHAGE-LAMBDA DETERMINE THE RATE OF ITS TRANSLATION INITIATION [J].
ALTUVIA, S ;
KORNITZER, D ;
TEFF, D ;
OPPENHEIM, AB .
JOURNAL OF MOLECULAR BIOLOGY, 1989, 210 (02) :265-280
[2]   fhlA repression by OxyS RNA:: Kissing complex formation at two sites results in a stable antisense-target RNA complex [J].
Argaman, L ;
Altuvia, S .
JOURNAL OF MOLECULAR BIOLOGY, 2000, 300 (05) :1101-1112
[3]   Regulation of transcription attenuation and translation initiation by allosteric control of an RNA-binding protein:: the Bacillus subtilis TRAP protein [J].
Babitzke, P .
CURRENT OPINION IN MICROBIOLOGY, 2004, 7 (02) :132-139
[4]   New RNA motifs suggest an expanded scope for riboswitches in bacterial genetic control [J].
Barrick, JE ;
Corbino, KA ;
Winkler, WC ;
Nahvi, A ;
Mandal, M ;
Collins, J ;
Lee, M ;
Roth, A ;
Sudarsan, N ;
Jona, I ;
Wickiser, JK ;
Breaker, RR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (17) :6421-6426
[5]   Structure of a natural guanine-responsive riboswitch complexed with the metabolite hypoxanthine [J].
Batey, RT ;
Gilbert, SD ;
Montange, RK .
NATURE, 2004, 432 (7015) :411-415
[6]  
BOY E, 1979, BIOCHIMIE, V61, P1151
[7]   Engineered allosteric ribozymes as biosensor components [J].
Breaker, RR .
CURRENT OPINION IN BIOTECHNOLOGY, 2002, 13 (01) :31-39
[8]   Natural and engineered nucleic acids as tools to explore biology [J].
Breaker, RR .
NATURE, 2004, 432 (7019) :838-845
[9]   The regulation of bacterial transcription initiation [J].
Browning, DF ;
Busby, SJW .
NATURE REVIEWS MICROBIOLOGY, 2004, 2 (01) :57-65
[10]   Xanthine metabolism in Bacillus subtilis: Characterization of the xpt-pbuX operon and evidence for purine- and nitrogen-controlled expression of genes involved in xanthine salvage and catabolism [J].
Christiansen, LC ;
Schou, S ;
Nygaard, P ;
Saxild, HH .
JOURNAL OF BACTERIOLOGY, 1997, 179 (08) :2540-2550
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