Coordinated Regulation of PPARγ Expression and Activity through Control of Chromatin Structure in Adipogenesis and Obesity

被引：36
作者：
Eeckhoute, Jerome [1 ,2 ,3 ,4 ]
Oger, Frederik [1 ,2 ,3 ,4 ]
Staels, Bart [1 ,2 ,3 ,4 ]
Lefebvre, Philippe [1 ,2 ,3 ,4 ]
机构：
[1] Univ Lille Nord France, F-59000 Lille, France
[2] INSERM, U1011, F-59000 Lille, France
[3] UDSL, F-59000 Lille, France
[4] Inst Pasteur, F-59019 Lille, France
来源：
PPAR RESEARCH | 2012年 / 2012卷
关键词：
ACTIVATED-RECEPTOR-GAMMA; RNA-POLYMERASE-II; VISCERAL ADIPOSE-TISSUE; GENE-EXPRESSION; TRANSCRIPTION FACTORS; HISTONE H3; ADIPOCYTE DIFFERENTIATION; NUCLEOSOME ORGANIZATION; ANTIDIABETIC ACTIONS; KEY REGULATOR;
D O I：
10.1155/2012/164140
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR gamma) is required for differentiation and function of mature adipocytes. Its expression is induced during adipogenesis where it plays a key role in establishing the transcriptome of terminally differentiated white fat cells. Here, we review findings indicating that PPAR gamma expression and activity are intricately regulated through control of chromatin structure. Hierarchical and combinatorial activation of transcription factors, noncoding RNAs, and chromatin remodelers allows for temporally controlled expression of PPAR gamma and its target genes through sequential chromatin remodelling. In obesity, these regulatory pathways may be altered and lead to modified PPAR gamma activity.
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页数：9
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