Natural Sources, Pharmacokinetics, Biological Activities and Health Benefits of Hydroxycinnamic Acids and Their Metabolites

被引：131

作者：

Sova, Matej ^{[1
]}

Saso, Luciano ^{[2
]}

机构：

[1] Univ Ljubljana, Fac Pharm, Askerceva 7, Ljubljana 1000, Slovenia

[2] Sapienza Univ Rome, Dept Physiol & Pharmacol Vittorio Erspamer, Piazzale Aldo Moro 5, I-00185 Rome, Italy

来源：

NUTRIENTS | 2020年 / 12卷 / 08期

关键词：

diet; natural compounds; phenolic acids; hydroxycinnamic acids; metabolites; pharmacokinetic properties; biological activities; health effects; P-COUMARIC ACID; COPRINOPSIS-ATRAMENTARIA EXTRACT; CAFFEIC ACID; FERULIC ACID; IN-VITRO; ANTIOXIDANT ACTIVITY; DIHYDROCAFFEIC ACID; CHLOROGENIC ACID; PHENOLIC-ACIDS; OXIDATIVE STRESS;

D O I：

10.3390/nu12082190

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Hydroxycinnamic acids (HCAs) are important natural phenolic compounds present in high concentrations in fruits, vegetables, cereals, coffee, tea and wine. Many health beneficial effects have been acknowledged in food products rich in HCAs; however, food processing, dietary intake, bioaccessibility and pharmacokinetics have a high impact on HCAs to reach the target tissue in order to exert their biological activities. In particular, metabolism is of high importance since HCAs' metabolites could either lose the activity or be even more potent compared to the parent compounds. In this review, natural sources and pharmacokinetic properties of HCAs and their esters are presented and discussed. The main focus is on their metabolism along with biological activities and health benefits. Special emphasis is given on specific effects of HCAs' metabolites in comparison with their parent compounds.

引用

页码：1 / 30

页数：30