QTL for survival to UV-C radiation in Drosophila melanogaster

被引：5

作者：

Gomez, Federico H. ^{[1
]}

Loeschcke, Volker ^{[2
]}

Norry, Fabian M. ^{[1
]}

机构：

[1] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Ecol Genet & Evoluc, RA-1428 Buenos Aires, DF, Argentina

[2] Aarhus Univ, Dept Biosci Integrat Ecol & Evolut, Aarhus C, Denmark

来源：

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | 2013年 / 89卷 / 07期

关键词：

Ultraviolet radiation; multiple trait mapping; environmental stress; thermotolerance; QUANTITATIVE TRAIT LOCI; INDUCED DNA-DAMAGE; KNOCKDOWN RESISTANCE; ULTRAVIOLET RESISTANCE; CELL-DEATH; CHILL-COMA; GENE; STRESS; LIGHT; HEAT;

D O I：

10.3109/09553002.2012.711503

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Purpose : The aim of this study was to investigate tolerance to UV-C (ultraviolet C, 280-100 nm) radiation in Drosophila melanogaster, implementing a quantitative trait locus (QTL) mapping approach. This is of interest to test for genetic variation in survival to UV (ultraviolet) radiation. Materials and methods : We performed a QTL scan in D. melanogaster recombinant inbred lines (RIL) constructed from parental stocks derived from a crossing between northern and southern hemisphere populations that segregated substantial genetic variation in thermal resistance in a previous study. Here, two experimental treatments were implemented: Continuous and cyclic UV-C radiation. Results : Significant QTL were detected on all three major chromosomes. Among these, multiple trait composite interval mapping revealed a significant QTL in the pericentromeric region of chromosome 2, a genome region consistently implicated in thermotolerance in previous studies. Conclusions : This study shows substantial genetic variation for UV-C radiation resistance in D. melanogaster, with QTL for survival to UV-C radiation generally overlapping with major thermotolerance QTL. The genetic architecture of UV-C radiation resistance appears to be more complex in continuously irradiated individuals.

引用

页码：583 / 589

页数：7

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