Ectodysplasin/NF-κB Signaling in Embryonic Mammary Gland Development

被引：33

作者：

Lindfors, Paivi H. ^{[1
]}

Voutilainen, Maria ^{[1
]}

Mikkola, Marja L. ^{[1
]}

机构：

[1] Univ Helsinki, Inst Biotechnol, Dev Biol Program, Helsinki 00014, Finland

来源：

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA | 2013年 / 18卷 / 02期

关键词：

Ectodermal dysplasia; HED; Breast; Placode; Branching; Duct; HYPOHIDROTIC ECTODERMAL DYSPLASIA; TRANSGENIC MICE; HAIR-FOLLICLES; FEMALE MICE; CELL FATE; EDAR; MORPHOGENESIS; GENE; EXPRESSION; PATHWAYS;

D O I：

10.1007/s10911-013-9277-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The ectodysplasin (Eda) signaling pathway consists of a TNF-like ligand Eda, its receptor Edar, and an adaptor protein Edaradd and its activation leads to NF-kappa B mediated transcription. In humans, mutations in the EDA pathway genes cause hypohidrotic ectodermal dysplasia, a disorder characterized by defective formation of hair follicles, teeth, and several exocrine glands including the breast. Embryonic mammary gland development proceeds via placode, bud, bulb and sprout stages before the onset of branching morphogenesis. Studies on mouse models have linked Eda with two aspects of embryonic mammary gland morphogenesis: placode induction and ductal growth and branching. Here we summarize the current knowledge on the role of Eda/NF-kappa B in mammary gland development.

引用

页码：165 / 169

页数：5

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