An efficient catalyst-free Mukaiyama-aldol reaction of fluorinated enol silyl ethers with tryptanthrin

被引：45

作者：

Liao, Fu-Min ^{[1
]}

Liu, Yun-Lin ^{[1
]}

Yu, Jin-Sheng ^{[1
]}

Zhou, Feng ^{[1
]}

Zhou, Jian ^{[1
,2
]}

机构：

[1] E China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 33期

关键词：

PROMOTED ORGANIC-REACTIONS; DIFLUOROENOL SILYL; ENANTIOSELECTIVE FLUORINATION; ASYMMETRIC FLUORINATION; DANISHEFSKYS DIENE; STRECKER REACTION; HIGHLY EFFICIENT; TRIFLUOROMETHYLATION; CARBONYL; KETONES;

D O I：

10.1039/c5ob01125f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report an efficient Mukaiyama-aldol reaction of tryptanthrin with fluorinated enol silyl ethers, which is carried out in methanol without the use of any catalyst. This method is applied to the total synthesis of the difluoro analogues of the natural product Phaitanthrin B.

引用

页码：8906 / 8911

页数：6

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