Recent advances in pharmaceutical applications of chiral capillary electrophoresis

被引：111

作者：

Ha, PTT ^{[1
]}

Hoogmartens, J ^{[1
]}

Van Schepdael, A ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Fac Pharmaceut Sci, Lab Pharamaceut Chem & Drug Anal, B-3000 Louvain, Belgium

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2006年 / 41卷 / 01期

关键词：

capillary electrophoresis; chiral; overview;

D O I：

10.1016/j.jpba.2006.01.035

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This review article summarizes developments and applications of chiral capillary electrophoresis (CE) in the pharmaceutical field published from January 2004 to June 2005. Due to the tremendous number of publications, this article is aimed to focus on major developments in chiral separations and some selected applications rather than to provide a descriptive overview of all published papers. Valuable information is also collected from several excellent reviews published during this period. Developments are classified according to CE modes, namely capillary zone electrophoresis (CZE), micellar electrokinetic capillary chromatography (MEKC), microemulsion electrokinetic chromatography (MEEKC). In the CZE section, different types of chiral selectors including cyclodextrins, oligo- and polysaccharides, crown ethers, macrocyclic antibiotics, ligand exchange systems and proteins are described. Nonaqueous capillary electrophoresis is also included in this section. Coupling CE to MS is discussed in a separate part, followed by a summary of selected pharmaceutical applications of enantioselective CE. Finally, sorne conclusions are drawn and prospects of CE in chiral analysis are also drafted. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：1 / 11

页数：11

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[21] 3-amino derivative of β-cyclodextrin:: thermodynamics of copper(II) complexes and exploitation of its enantioselectivity in the separation of amino acid racemates by ligand exchange capillary electrophoresis [J].