Recent advances in pharmaceutical applications of chiral capillary electrophoresis

被引：111
作者：
Ha, PTT [1 ]
Hoogmartens, J [1 ]
Van Schepdael, A [1 ]
机构：
[1] Katholieke Univ Leuven, Fac Pharmaceut Sci, Lab Pharamaceut Chem & Drug Anal, B-3000 Louvain, Belgium
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2006年 / 41卷 / 01期
关键词：
capillary electrophoresis; chiral; overview;
D O I：
10.1016/j.jpba.2006.01.035
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
This review article summarizes developments and applications of chiral capillary electrophoresis (CE) in the pharmaceutical field published from January 2004 to June 2005. Due to the tremendous number of publications, this article is aimed to focus on major developments in chiral separations and some selected applications rather than to provide a descriptive overview of all published papers. Valuable information is also collected from several excellent reviews published during this period. Developments are classified according to CE modes, namely capillary zone electrophoresis (CZE), micellar electrokinetic capillary chromatography (MEKC), microemulsion electrokinetic chromatography (MEEKC). In the CZE section, different types of chiral selectors including cyclodextrins, oligo- and polysaccharides, crown ethers, macrocyclic antibiotics, ligand exchange systems and proteins are described. Nonaqueous capillary electrophoresis is also included in this section. Coupling CE to MS is discussed in a separate part, followed by a summary of selected pharmaceutical applications of enantioselective CE. Finally, sorne conclusions are drawn and prospects of CE in chiral analysis are also drafted. (c) 2006 Elsevier B.V. All rights reserved.
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页码：1 / 11
页数：11
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  • [21] 3-amino derivative of β-cyclodextrin:: thermodynamics of copper(II) complexes and exploitation of its enantioselectivity in the separation of amino acid racemates by ligand exchange capillary electrophoresis
    Cucinotta, V
    Giuffrida, A
    La Mendola, D
    Maccarrone, G
    Puglisi, A
    Rizzarelli, E
    Vecchio, G
    [J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2004, 800 (1-2): : 127 - 133
  • [22] Evaluation of newly synthesized and commercially available charged cyclomaltooligosaccharides (cyclodextrins) for capillary electrokinetic chromatography
    Culha, M
    Schell, FM
    Fox, S
    Green, T
    Betts, T
    Sepaniak, MJ
    [J]. CARBOHYDRATE RESEARCH, 2004, 339 (02) : 241 - 249
  • [23] Stereoselective peptide analysis
    Czerwenka, C
    Lindner, W
    [J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2005, 382 (03) : 599 - 638
  • [24] Separation of etodolac enantiomers by capillary electrophoresis.: Validation and application of the chiral method to the analysis of commercial formulations
    de Pablos, RR
    García-Ruiz, C
    Crego, AL
    Marina, ML
    [J]. ELECTROPHORESIS, 2005, 26 (06) : 1106 - 1113
  • [25] Cationic vesicles as chiral selector for enantioseparations of nonsteroidal antiinflammatory drugs by micellar electrokinetic chromatography
    Dey, J
    Mohanty, A
    Roy, S
    Khatua, D
    [J]. JOURNAL OF CHROMATOGRAPHY A, 2004, 1048 (01) : 127 - 132
  • [26] NMR studies of chiral recognition by cyclodextrins
    Dodziuk, H
    Kozminski, W
    Ejchart, A
    [J]. CHIRALITY, 2004, 16 (02) : 90 - 105
  • [27] Chiral separation of anticholinergic drug enantiomers in nonaqueous capillary electrophoresis
    Du, GH
    Zhang, SZ
    Xie, JW
    Zhong, BH
    Liu, KL
    [J]. JOURNAL OF CHROMATOGRAPHY A, 2005, 1074 (1-2) : 195 - 200
  • [28] Dynamics of interconversion of enantiomers in chiral separation systems:: A novel approach for determination of all rate constants involved in the interconversion
    Dubsky, P
    Tesarová, E
    Gas, B
    [J]. ELECTROPHORESIS, 2004, 25 (4-5) : 733 - 742
  • [29] Enantio selective capillary electrophoretic separation of tryptophane- and tyro sine-methylesters in a dual system with a tetra-oxadiaza-crown-ether derivative and a cyclodextrin
    Elek, J
    Mangelings, D
    Iványi, T
    Lázár, I
    Vander Heyden, Y
    [J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2005, 38 (04) : 601 - 608
  • [30] Chiral separation of N-imidazole derivatives aromatase inhibitors, by cyclodextrin-capillary zone electrophoresis.: Mechanism of enantioselective recognition
    Foulon, C
    Danel, C
    Vaccher, MP
    Bonte, JP
    Vaccher, C
    Jean-François, J
    [J]. ELECTROPHORESIS, 2004, 25 (16) : 2735 - 2744
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