Iron-Catalyzed C-H Alkylation of Heterocyclic C-H Bonds

被引：70

作者：

Babu, Kaki Raveendra ^{[1
]}

Zhu, Nengbo ^{[1
]}

Bao, Hongli ^{[1
]}

机构：

[1] Univ Chinese Acad Sci, Fujian Inst Res Struct Matter, State Key Lab Struct Chem, Key Lab Coal Ethylene Glycol & Its Related Techno, 155 Yangqiao Rd West, Fuzhou 350002, Fujian, Peoples R China

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 01期

关键词：

ELECTRON-TRANSFER MECHANISM; REDOX-ACTIVE ESTERS; DIRECT ARYLATION; INTERMOLECULAR HYDROARYLATION; DIRECT ALKYNYLATION; CONJUGATE ADDITION; GRIGNARD-REAGENTS; CARBOXYLIC-ACIDS; MILD CONDITIONS; INDOLES;

D O I：

10.1021/acs.orglett.6b03287

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient, iron-catalyzed C-H alkylation of benzothiazoles by using alkyl diacyl peroxides and alkyl tert-butyl peresters which are readily accessible from carboxylic acids to synthesize 2-alkylbenzothiazoles is developed. This reaction is environmentally benign and compatible with a broad range of functional groups. Various primary, secondary, and tertiary alkyl groups can be efficiently incorporated into diverse benzothiazoles. The effectiveness of this method is illustrated by late-stage functionalization of biologically active heterocycles.

引用

页码：46 / 49

页数：4

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