Mitogen-activated protein kinase signaling pathway in oral cancer (Review)

被引：100

作者：

Peng, Qian ^{[1
]}

Deng, Zhiyuan ^{[1
]}

Pan, Hao ^{[1
]}

Gu, Liqun ^{[1
]}

Liu, Ousheng ^{[1
]}

Tang, Zhangui ^{[1
]}

机构：

[1] Cent S Univ, Xiangya Stomatol Hosp, 72 Xiangya Rd, Changsha 410008, Hunan, Peoples R China

来源：

ONCOLOGY LETTERS | 2018年 / 15卷 / 02期

基金：

中国国家自然科学基金;

关键词：

mitogen-activated protein kinase signaling pathway; oral cancer; oral squamous cell carcinoma; kinase; therapeutic targets; inhibitor; treatment; SQUAMOUS-CELL CARCINOMA; MAP KINASE; DIFFERENTIAL REGULATION; COLORECTAL-CANCER; ERK PATHWAY; PROLIFERATION; MODULATION; APOPTOSIS; HEAD; P38;

D O I：

10.3892/ol.2017.7491

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The mitogen-activated protein kinase (MAPK) signaling pathway is associated with tumor cell proliferation, differentiation, apoptosis, angiogenesis, invasion and metastasis. The present review assesses the involvement of the MAPK signaling pathway in oral cancer progression and invasion based on analysis of individual sub-pathways and their mechanisms of action. The regulation of this pathway for targeted oral cancer therapy is explored and the challenges confronting this, as well as corresponding potential solutions, are discussed. Exploring this pathway with an emphasis on its components, subfamilies, sub-pathways, interactions with other pathways and clinical practice modes may improve oral cancer treatment.

引用

页码：1379 / 1388

页数：10

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