IS CELL CYCLE A PERFECT FAULT TOLERANT CONTROL SYSTEM? - SYSTEM ENGINEERING POINT OF VIEW

被引：0
作者：
Swierniak, Andrzej [1 ]
Jaksik, Roman [1 ]
Smieja, Jaroslaw [1 ]
机构：
[1] Silesian Tech Univ, Dept Automat Control, Akad 2A, PL-44100 Gliwice, Poland
来源：
2017 13TH IASTED INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING (BIOMED) | 2017年
关键词：
Cell cycle; DNA damage-repair; fault-prone system; p53 regulatory module; SIGNALING PATHWAYS; DNA-DAMAGE; P53; RADIATION; BINDING; REPAIR;
D O I：
10.2316/P.2017.852-005
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
We present a system engineering approach to a problem of DNA damage-repair in hwnan cells. We discuss chosen control systems existing in the cells and demonstrate that they constitute an almost perfect fault tolerant system. We discuss the consequences of gaps in this system and explain why it cannot be completely perfect.
引用
收藏
页码：108 / 113
页数：6
相关论文
共 50 条
[41]   Control of cell divisions in the nervous system: Symmetry and asymmetry [J].
Lu, BW ;
Jan, L ;
Jan, YN .
ANNUAL REVIEW OF NEUROSCIENCE, 2000, 23 :531-556
[42]   The impact of calmodulin on the cell cycle analyzed in a novel human cellular genetic system [J].
Munk, Mads ;
Alcalde, Juan ;
Lorentzen, Lasse ;
Villalobo, Antonio ;
Berchtold, Martin W. ;
Panina, Svetlana .
CELL CALCIUM, 2020, 88
[43]   The clock is ticking. Ageing of the circadian system: From physiology to cell cycle [J].
Terzibasi-Tozzini, Eva ;
Martinez-Nicolas, Antonio ;
Lucas-Sanchez, Alejandro .
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2017, 70 :164-176
[44]   Cell Cycle Re-entry in the Nervous System: From Polyploidy to Neurodegeneration [J].
Nandakumar, Shyama ;
Rozich, Emily ;
Buttitta, Laura .
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 9
[45]   CycleTrak: A novel system for the semi-automated analysis of cell cycle dynamics [J].
Ridenour, Dennis A. ;
McKinney, Mary Cathleen ;
Bailey, Caleb M. ;
Kulesa, Paul M. .
DEVELOPMENTAL BIOLOGY, 2012, 365 (01) :189-195
[46]   Cell cycle and cell fate in the developing nervous system: the role of CDC25B phosphatase [J].
Eric Agius ;
Sophie Bel-Vialar ;
Frédéric Bonnet ;
Fabienne Pituello .
Cell and Tissue Research, 2015, 359 :201-213
[47]   Cell cycle and cell fate in the developing nervous system: the role of CDC25B phosphatase [J].
Agius, Eric ;
Bel-Vialar, Sophie ;
Bonnet, Frederic ;
Pituello, Fabienne .
CELL AND TISSUE RESEARCH, 2015, 359 (01) :201-213
[48]   A mammalian myocardial cell-free system to study cell cycle reentry in terminally differentiated cardiomyocytes [J].
Engel, FB ;
Hauck, L ;
Cardoso, MC ;
Leonhardt, H ;
Dietz, R ;
von Harsdorf, R .
CIRCULATION RESEARCH, 1999, 85 (03) :294-301
[49]   Characterising the Behaviour of a Structured PDE Model of the Cell Cycle in Contrast to a Corresponding ODE System [J].
Nixson, Ruby E. ;
Byrne, Helen M. ;
Pitt-Francis, Joe M. ;
Maini, Philip K. .
BULLETIN OF MATHEMATICAL BIOLOGY, 2025, 87 (07)
[50]   Identification and characterization of distinct cell cycle stages in cardiomyocytes using the FUCCI transgenic system [J].
Baniol, Marion ;
Murganti, Francesca ;
Smialowska, Agata ;
Panula, Joni ;
Lazar, Eniko ;
Brockman, Viveka ;
Giatrellis, Sarantis ;
Derks, Wouter ;
Bergmann, Olaf .
EXPERIMENTAL CELL RESEARCH, 2021, 408 (02)
12345