IS CELL CYCLE A PERFECT FAULT TOLERANT CONTROL SYSTEM? - SYSTEM ENGINEERING POINT OF VIEW

被引：0
作者：
Swierniak, Andrzej [1 ]
Jaksik, Roman [1 ]
Smieja, Jaroslaw [1 ]
机构：
[1] Silesian Tech Univ, Dept Automat Control, Akad 2A, PL-44100 Gliwice, Poland
来源：
2017 13TH IASTED INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING (BIOMED) | 2017年
关键词：
Cell cycle; DNA damage-repair; fault-prone system; p53 regulatory module; SIGNALING PATHWAYS; DNA-DAMAGE; P53; RADIATION; BINDING; REPAIR;
D O I：
10.2316/P.2017.852-005
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
We present a system engineering approach to a problem of DNA damage-repair in hwnan cells. We discuss chosen control systems existing in the cells and demonstrate that they constitute an almost perfect fault tolerant system. We discuss the consequences of gaps in this system and explain why it cannot be completely perfect.
引用
收藏
页码：108 / 113
页数：6
相关论文
共 50 条
[21]   Regulation of the endothelial cell cycle by the ubiquitin-proteasome system [J].
Fasanaro, Pasquale ;
Capogrossi, Maurizio C. ;
Martelli, Fabio .
CARDIOVASCULAR RESEARCH, 2010, 85 (02) :272-280
[22]   Neural cell cycle dysregulation and central nervous system diseases [J].
Wang, Wei ;
Bu, Bitao ;
Xie, Minjie ;
Zhang, Min ;
Yu, Zhiyuan ;
Tao, Deding .
PROGRESS IN NEUROBIOLOGY, 2009, 89 (01) :1-17
[23]   Novel functions for cell cycle genes in nervous system development [J].
McClellan, Kelly A. ;
Slack, Ruth S. .
CELL CYCLE, 2006, 5 (14) :1506-1513
[24]   HCCDB: Data mining system for human cell cycle gene [J].
Milanesi, L. ;
Alfieri, R. ;
Merelli, I .
PROCEEDINGS OF THE FIFTH INTERNATIONAL CONFERENCE ON BIOINFORMATICS OF GENOME REGULATION AND STRUCTURE, VOL 2, 2006, :145-+
[25]   Natural Autoantibodies: An Undersugn Hero of the Immune System and Autoimmune Disorders-A Point of View [J].
Avrameas, Stratis ;
Alexopoulos, Haris ;
Moutsopoulos, Harry M. .
FRONTIERS IN IMMUNOLOGY, 2018, 9
[26]   Cisplatin-resistant prostate cancer model: Differences in antioxidant system, apoptosis and cell cycle [J].
Gumulec, Jaromir ;
Balvan, Jan ;
Sztalmachova, Marketa ;
Raudenska, Martina ;
Dvorakova, Veronika ;
Knopfova, Lucia ;
Polanska, Hana ;
Hudcova, Kristyna ;
Ruttkay-Nedecky, Branislav ;
Babula, Petr ;
Adam, Vojtech ;
Kizek, Rene ;
Stiborova, Marie ;
Masarik, Michal .
INTERNATIONAL JOURNAL OF ONCOLOGY, 2014, 44 (03) :923-933
[27]   Improved gene amplification by cell-cycle engineering combined with the Cre-loxP system in Chinese hamster ovary cells [J].
Matsuyama, Rima ;
Tsutsui, Tomomi ;
Lee, Kyoung Ho ;
Onitsuka, Masayoshi ;
Omasa, Takeshi .
JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 2015, 120 (06) :701-708
[28]   UVB Inhibits Proliferation, Cell Cycle and Induces Apoptosis via p53, E2F1 and Microtubules System in Cervical Cancer Cell Lines [J].
Granados-Lopez, Angelica Judith ;
Manzanares-Acuna, Eduardo ;
Lopez-Hernandez, Yamile ;
Castaneda-Delgado, Julio Enrique ;
Fraire-Soto, Ixamail ;
Reyes-Estrada, Claudia Araceli ;
Gutierrez-Hernandez, Rosalinda ;
Lopez, Jesus Adrian .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (10)
[29]   Reverse Engineering the Yeast RNR1 Transcriptional Control System [J].
Mao, Grace ;
Brody, James P. .
PLOS ONE, 2010, 5 (11)
[30]   Genotoxic and cytotoxic effects of aflatoxin on the reproductive system: Focus on cell cycle dynamics and apoptosis in testicular tissue [J].
Jalili, Cyrus ;
Shamsi, Rahele Ranjbar ;
Amiri, Bita ;
Kakebaraie, Seyran ;
Jalili, Faramarz ;
Nasta, Touraj Zamir .
TOXICOLOGY, 2024, 504
12345