Management of mycosis fungoides-type cutaneous T-cell lymphoma (MF-CTCL): focus on chlormethine gel

被引：17

作者：

Denis, Daphne ^{[1
]}

Beneton, Nathalie ^{[1
]}

Laribi, Kamel ^{[2
]}

Maillard, Herve ^{[1
]}

机构：

[1] Ctr Hosp Le Mans, Dermatol Dept, 194 Ave Rubillard, F-72037 Le Mans, France

[2] Ctr Hosp Le Mans, Haematol Dept, Le Mans, France

来源：

CANCER MANAGEMENT AND RESEARCH | 2019年 / 11卷

关键词：

mycosis fungoides; nitrogen mustard; mechlorethamine; chlormethine; gel; TOPICAL NITROGEN-MUSTARD; LOW-DOSE METHOTREXATE; EUROPEAN-ORGANIZATION; INTERNATIONAL-SOCIETY; PROGNOSTIC-FACTORS; MULTICENTER-TRIAL; SEZARY-SYNDROME; THERAPY; MECHLORETHAMINE; CLASSIFICATION;

D O I：

10.2147/CMAR.S138661

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mycosis fungoides (MF) is a low-grade cutaneous lymphoma accounting for more than half of primary cutaneous T-cell lymphomas (CTCLs). Due to the rarity of CTCL, randomized studies are lacking, and treatment is based mainly on the recent published European Organisation for Research and Treatment of Cancer guidelines. Basically, early-stage MF is treated with skin-directed treatments, whereas advanced-stage MF requires more aggressive therapies. Among the skin-directed therapies, nitrogen mustard has been used for more than 50 years. A gel formulation was developed recently, showing a slight decrease in efficacy, counterbalanced by better tolerance (essentially due to a decrease in delayed hypersensitivity reactions). This review aims to summarize the current management of MF and the role of chlormethine gel in the treatment of the disease.

引用

页码：2241 / 2251

页数：11

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