Genetics of sarcoidosis

被引：58
作者：
Mueller-Quernheim, Joachim [1 ]
Schuermann, Manfred [2 ]
Hofmann, Sylvia [3 ]
Gaede, Karoline I. [4 ]
Fischer, Annegret [3 ]
Prasse, Antje [1 ]
Zissel, Gernot [1 ]
Schreiber, Stefan [3 ,5 ]
机构：
[1] Univ Med Ctr, Dept Pneumol, D-79106 Freiburg, Germany
[2] Med Univ Lubeck, Med Univ Schleswig Holstein, Inst Human Genet, D-23538 Lubeck, Germany
[3] Univ Kiel, Inst Clin Mol Biol, D-24105 Kiel, Germany
[4] Res Ctr Borstel, Dept Clin Med, D-23845 Borstel, Germany
[5] Univ Kiel, Dept Gen Internal Med, D-24105 Kiel, Germany
来源：
CLINICS IN CHEST MEDICINE | 2008年 / 29卷 / 03期
关键词：
D O I：
10.1016/j.ccm.2008.03.007
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Sarcoidosis is a multigenic and multifactorial disease. Predisposing genes have been identified and fast progress in molecular technologies including systematic genome-wide association studies and large-scale resequencing will aid the discovery of further risk loci and variants. The exploration of the molecular epidemiology of genetic variants in the pathogenesis of sarcoidosis will allow an assessment of their prognostic usefulness. To this end, different granulomatous disorders of known and unknown etiology should be investigated jointly by genetic, immunobiological, and proteomic approaches. The definition of individual genetic risk profiles in sarcoidosis and other chronic inflammatory disorders seems achievable and a useful route for clinical translation.
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收藏
页码：391 / +
页数：25
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