ACETANILIDE: SOLVENT-FREE GREEN SYNTHESIS

被引：7

作者：

Cunha, Silvio ^{[1
,2
]}

dos Santos da Costa, Otelicio Bispo ^{[1
,2
]}

Botelho de Santana, Lourenco Luis ^{[1
,2
]}

Lopes, Wilson Araujo ^{[1
,2
]}

机构：

[1] Univ Fed Bahia, Inst Quim, BR-40170290 Salvador, BA, Brazil

[2] Univ Fed Bahia, Inst Nacl Ciencia & Tecnol Energia & Ambiente, BR-40170290 Salvador, BA, Brazil

来源：

QUIMICA NOVA | 2015年 / 38卷 / 06期

关键词：

green chemistry; acetanilide; aniline; undergraduate organic chemistry experiment; solventless reaction; ATOM ECONOMY; CHEMISTRY; CATALYSIS; ACID;

D O I：

10.5935/0100-4042.20150080

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We described herein a solvent-free synthesis of acetanilide developed in the context of green chemistry. The synthetic approach consisted of the reaction of aniline with acetic anhydride without additives, while using smaller amounts of reagents and water than previously described for this undergraduate experiment. The E Factor was 0.6 by experienced chemists and 0.9 by students.

引用

页码：874 / 876

页数：3

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