Collagenases and cracks in the plaque

被引：91

作者：

Libby, Peter ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Cardiovasc Med,Dept Med, Boston, MA 02115 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2013年 / 123卷 / 08期

关键词：

ACUTE MYOCARDIAL-INFARCTION; ACUTE CORONARY SYNDROMES; ATHEROSCLEROTIC PLAQUES; MATRIX METALLOPROTEINASES; RABBIT ATHEROMA; EXPRESSION; STABILIZATION; ACCUMULATION; MACROPHAGES; ULTRASOUND;

D O I：

10.1172/JCI67526

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The core of an atheromatous plaque contains lipids, macrophages, and cellular debris, typically covered by a fibrous cap that separates the thrombogenic core from the blood. Rupture of the fibrous cap causes most fatal myocardial infarctions. Interstitial collagen confers tensile strength on the cap, as it does in skin and tendons. In 1994, Peter Libby and colleagues demonstrated overexpression of collagenolytic enzymes in atheromatous plaques and implicated MMPs in the destabilization of these lesions.

引用

收藏

页码：3201 / 3203

页数：3

相关论文

共 23 条

[1] Dietary lipid lowering reduces tissue factor expression in rabbit atheroma [J].

Aikawa, M ;

Voglic, SJ ;

Sugiyama, S ;

Rabkin, E ;

Taubman, MB ;

Fallon, JT ;

Libby, P .

CIRCULATION, 1999, 100 (11) :1215-1222

[2] Lipid lowering by diet reduces matrix metalloproteinase activity and increases collagen content of rabbit atheroma - A potential mechanism of lesion stabilization [J].

Aikawa, M ;

Rabkin, E ;

Okada, Y ;

Voglic, SJ ;

Clinton, SK ;

Brinckerhoff, CE ;

Sukhova, GK ;

Libby, P .

CIRCULATION, 1998, 97 (24) :2433-2444

[3]

Aikawa M, 2001, CIRCULATION, V103, P276

[4] Pravastatin treatment increases collagen content and decreases lipid content, inflammation, metalloproteinases, and cell death in human carotid plaques - Implications for plaque stabilization [J].

Crisby, M ;

Nordin-Fredriksson, G ;

Shah, PK ;

Yano, J ;

Zhu, J ;

Nilsson, J .

CIRCULATION, 2001, 103 (07) :926-933

[5] Matrix metalloproteinase-13/collagenase-3 deletion promotes collagen accumulation and organization in mouse atherosclerotic plaques [J].

Deguchi, JO ;

Aikawa, E ;

Libby, P ;

Vachon, JR ;

Inada, M ;

Krane, SM ;

Whittaker, P ;

Aikawa, M .

CIRCULATION, 2005, 112 (17) :2708-2715

[6] Genetically engineered resistance for MMP collagenases promotes abdominal aortic aneurysm formation in mice infused with angiotensin II [J].

Deguchi, Jun-o ;

Huang, Hayden ;

Libby, Peter ;

Aikawa, Elena ;

Whittaker, Peter ;

Sylvan, Jeremy ;

Lee, Richard T. ;

Aikawa, Masanori .

LABORATORY INVESTIGATION, 2009, 89 (03) :315-326

[7] Spotty calcification typifies the culprit plaque in patients with acute myocardial infarction - An intravascular ultrasound study [J].

Ehara, S ;

Kobayashi, Y ;

Yoshiyama, M ;

Shimada, K ;

Shimada, Y ;

Fukuda, D ;

Nakamura, Y ;

Yamashita, H ;

Yamagishi, H ;

Takeuchi, K ;

Naruko, T ;

Haze, K ;

Becker, AE ;

Yoshikawa, J ;

Ueda, M .

CIRCULATION, 2004, 110 (22) :3424-3429

[8] Update on acute coronary syndromes: the pathologists view [J].

Falk, Erling ;

Nakano, Masataka ;

Bentzon, Jacob Fog ;

Finn, Aloke V. ;

Virmani, Renu .

EUROPEAN HEART JOURNAL, 2013, 34 (10) :719-+

[9] Genetically determined resistance to collagenase action augments interstitial collagen accumulation in atherosclerotic plaques [J].

Fukumoto, Y ;

Deguchi, J ;

Libby, P ;

Rabkin-Aikawa, E ;

Sakata, Y ;

Chin, MT ;

Hill, CC ;

Lawler, PR ;

Varo, N ;

Schoen, FJ ;

Krane, SM ;

Aikawa, M .

CIRCULATION, 2004, 110 (14) :1953-1959

[10]

Fukumoto Y, 2001, CIRCULATION, V103, P993