Cancer Stem Cells (CSCs) in Drug Resistance and their Therapeutic Implications in Cancer Treatment

被引：719

作者：

Lan Thi Hanh Phi ^{[1
]}

Sari, Ita Novita ^{[1
]}

Yang, Ying-Gui ^{[1
]}

Lee, Sang-Hyun ^{[1
]}

Jun, Nayoung ^{[1
]}

Kim, Kwang Seock ^{[1
]}

Lee, Yun Kyung ^{[1
]}

Kwon, Hyog Young ^{[1
]}

机构：

[1] Soonchunhyang Univ, Soonchunhyang Inst Medi Biosci SIMS, Asan, South Korea

来源：

STEM CELLS INTERNATIONAL | 2018年 / 2018卷

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; TUMOR-INITIATING CELLS; ACUTE MYELOID-LEUKEMIA; ALDEHYDE DEHYDROGENASE-ACTIVITY; HEDGEHOG-SIGNALING PATHWAY; SELF-RENEWAL; PROSTATE-CANCER; ENDOTHELIAL-CELLS; SIDE POPULATION; SOLID TUMORS;

D O I：

10.1155/2018/5416923

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Cancer stem cells (CSCs), also known as tumor-initiating cells (TICs), are suggested to be responsible for drug resistance and cancer relapse due in part to their ability to self-renew themselves and differentiate into heterogeneous lineages of cancer cells. Thus, it is important to understand the characteristics and mechanisms by which CSCs display resistance to therapeutic agents. In this review, we highlight the key features and mechanisms that regulate CSC function in drug resistance as well as recent breakthroughs of therapeutic approaches for targeting CSCs. This promises new insights of CSCs in drug resistance and provides better therapeutic rationales to accompany novel anticancer therapeutics.

引用

页数：16

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