An Iron/Amine-Catalyzed Cascade Process for the Enantioselective Functionalization of Allylic Alcohols

被引：137
作者：
Quintard, Adrien [1 ]
Constantieux, Thierry [1 ]
Rodriguez, Jean [1 ]
机构：
[1] Aix Marseille Univ, Cent Marseille, CNRS, ISm2,UMR 7313, F-13397 Marseille, France
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 49期
关键词：
asymmetric catalysis; dual catalysis; hydrogen transfer; iron; organocatalysis; MEDIATED 2+2+1 CYCLOADDITIONS; OPPENAUER-TYPE OXIDATION; METAL-DIENE COMPLEXES; C BOND FORMATION; TRANSITION-METAL; IRON-CATALYST; ALPHA; BETA-UNSATURATED ALDEHYDES; BORROWING HYDROGEN; ORGANIC-SYNTHESIS; CARBON-MONOXIDE;
D O I：
10.1002/anie.201307295
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Three is a lucky number: An enantioselective transformation of allylic alcohols into β-chiral saturated alcohols has been developed by combining two distinct metal- and organocatalyzed catalytic cycles. This waste-free triple cascade process merges an iron-catalyzed borrowing-hydrogen step with an aminocatalyzed nucleophilic addition reaction. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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收藏
页码：12883 / 12887
页数：5
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