Human Amniotic Mesenchymal Stem Cells Promote Endogenous Bone Regeneration

被引：18
作者：
Li, Jin [1 ]
Zhou, Zhixuan [1 ,2 ]
Wen, Jin [3 ]
Jiang, Fei [1 ,2 ]
Xia, Yang [1 ,4 ]
机构：
[1] Nanjing Med Univ, Jiangsu Key Lab Oral Dis, Nanjing, Peoples R China
[2] Nanjing Med Univ, Affiliated Hosp Stomatol, Dept Gen Dent, Nanjing, Peoples R China
[3] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Prosthodont,Coll Stomatol, Shanghai, Peoples R China
[4] Nanjing Med Univ, Affiliated Hosp Stomatol, Dept Prosthodont, Nanjing, Peoples R China
来源：
FRONTIERS IN ENDOCRINOLOGY | 2020年 / 11卷
基金：
中国国家自然科学基金;
关键词：
hAMSCs; paracrine functions; endogenous bone regeneration; arthritis; bone defects; clinical trials; MEMBRANE-DERIVED CELLS; STROMAL CELLS; OSTEOGENIC DIFFERENTIATION; CONDITIONED MEDIUM; IMMUNOMODULATORY PROPERTIES; SYSTEMATIC ANALYSIS; UMBILICAL-CORD; GLOBAL BURDEN; DISEASE; MARROW;
D O I：
10.3389/fendo.2020.543623
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Bone regeneration has become a research hotspot and therapeutic target in the field of bone and joint medicine. Stem cell-based therapy aims to promote endogenous regeneration and improves therapeutic effects and side-effects of traditional reconstruction of significant bone defects and disorders. Human amniotic mesenchymal stem cells (hAMSCs) are seed cells with superior paracrine functions on immune-regulation, anti-inflammation, and vascularized tissue regeneration. The present review summarized the source and characteristics of hAMSCs and analyzed their roles in tissue regeneration. Next, the therapeutic effects and mechanisms of hAMSCs in promoting bone regeneration of joint diseases and bone defects. Finally, the clinical application of hAMSCs from current clinical trials was analyzed. Although more studies are needed to confirm that hAMSC-based therapy to treat bone diseases, the clinical application prospect of the approach is worth investigating.
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页数：9
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