Novel treatment strategies for feline chronic kidney disease: A critical look at the potential of mesenchymal stem cell therapy

被引：10

作者：

Quimby, J. M. ^{[1
]}

Dow, S. W. ^{[1
]}

机构：

[1] Colorado State Univ, Coll Vet Med & Biomed Sci, Dept Clin Sci, Ctr Immune & Regenerat Med, Ft Collins, CO 80523 USA

来源：

VETERINARY JOURNAL | 2015年 / 204卷 / 03期

关键词：

Cat; Nephrology; Mesenchymal stromal cell; Regenerative medicine; Renal; MARROW STROMAL CELLS; ADIPOSE-TISSUE; BONE-MARROW; RENAL-DISEASE; DONOR AGE; FAILURE; PROGRESSION; IMPROVEMENT; INJECTION; MODEL;

D O I：

10.1016/j.tvjl.2015.04.007

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Stem cell therapy is an innovative field of scientific investigation with tremendous potential for clinical application that holds promise for the treatment of a variety of diseases in veterinary medicine. Based on the known desirable properties of mesenchymal stem cells, the therapy has potential for treatment of both acute kidney injury and chronic kidney disease in cats. This review details terminology commonly used in this field of study, sources of mesenchymal stem cells and their proposed mechanism of action particularly as it relates to renal repair. Studies performed in rodent models of chronic kidney disease and feline clinical trial results are also summarized with the aim of providing an overview of the current status of this treatment modality and its potential for the future. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：241 / 246

页数：6

共 62 条

[1] Aggarwal S., 2013, STEM CELLS TRANSLATI, P1011
[2] Mesenchymal stem cells: immune evasive, not immune privileged
Ankrum, James A.
Ong, Joon Faii
Karp, Jeffrey M.
[J]. NATURE BIOTECHNOLOGY, 2014, 32 (03) : 252 - 260
[3] Immunogenicity of adult mesenchymal stem cells: Lessons from the fetal allograft
Barry, FP
Murphy, JM
English, K
Mahon, BP
[J]. STEM CELLS AND DEVELOPMENT, 2005, 14 (03) : 252 - 265
[4] Berent A., 2013, P AM COLL VET INT ME
[5] Mesenchymal Stem Cells Delivered at the Subcapsule of the Kidney Ameliorate Renal Disease in the Rat Remnant Kidney Model
Cavaglieri, R. C.
Martini, D.
Sogayar, M. C.
Noronha, I. L.
[J]. TRANSPLANTATION PROCEEDINGS, 2009, 41 (03) : 947 - 951
[6] Histomorphometry of Feline Chronic Kidney Disease and Correlation With Markers of Renal Dysfunction
Chakrabarti, S.
Syme, H. M.
Brown, C. A.
Elliott, J.
[J]. VETERINARY PATHOLOGY, 2013, 50 (01) : 147 - 155
[7] The Role of Mesenchymal Stem Cells in the Functional Improvement of Chronic Renal Failure
Choi, Soojeong
Park, Mooyong
Kim, Jinkuk
Hwang, Seungduk
Park, Seongkyu
Lee, Youkyoung
[J]. STEM CELLS AND DEVELOPMENT, 2009, 18 (03) : 521 - 529
[8] de Almeida Danilo C, 2013, Clin Biochem Rev, V34, P131
[9] Murine mesenchymal stem cells suppress dendritic cell migration, maturation and antigen presentation
English, Karen
Barry, Frank P.
Mahon, Bernard P.
[J]. IMMUNOLOGY LETTERS, 2008, 115 (01) : 50 - 58
[10] Effects of adipose-derived mesenchymal cells on ischemia-reperfusion injury in kidney
Furuichi, Kengo
Shintani, Hidemi
Sakai, Yoshio
Ochiya, Takahiro
Matsushima, Kouji
Kaneko, Shuichi
Wada, Takashi
[J]. CLINICAL AND EXPERIMENTAL NEPHROLOGY, 2012, 16 (05) : 679 - 689

← 1 2 3 4 5 6 7 →