Novel treatment strategies for feline chronic kidney disease: A critical look at the potential of mesenchymal stem cell therapy

被引：11

作者：

Quimby, J. M. ^{[1
]}

Dow, S. W. ^{[1
]}

机构：

[1] Colorado State Univ, Coll Vet Med & Biomed Sci, Dept Clin Sci, Ctr Immune & Regenerat Med, Ft Collins, CO 80523 USA

来源：

VETERINARY JOURNAL | 2015年 / 204卷 / 03期

关键词：

Cat; Nephrology; Mesenchymal stromal cell; Regenerative medicine; Renal; MARROW STROMAL CELLS; ADIPOSE-TISSUE; BONE-MARROW; RENAL-DISEASE; DONOR AGE; FAILURE; PROGRESSION; IMPROVEMENT; INJECTION; MODEL;

D O I：

10.1016/j.tvjl.2015.04.007

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Stem cell therapy is an innovative field of scientific investigation with tremendous potential for clinical application that holds promise for the treatment of a variety of diseases in veterinary medicine. Based on the known desirable properties of mesenchymal stem cells, the therapy has potential for treatment of both acute kidney injury and chronic kidney disease in cats. This review details terminology commonly used in this field of study, sources of mesenchymal stem cells and their proposed mechanism of action particularly as it relates to renal repair. Studies performed in rodent models of chronic kidney disease and feline clinical trial results are also summarized with the aim of providing an overview of the current status of this treatment modality and its potential for the future. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：241 / 246

页数：6

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