Synthesis and Anti-Inflammatory Activity of 1-Methylhydantoin Cinnamoyl Imides

被引：6

作者：

Wang, Shihan ^{[1
]}

Ji, Li ^{[1
]}

Zhang, Dongxue ^{[1
]}

Guo, Hongye ^{[2
]}

Wang, Yongsheng ^{[2
]}

Li, Wei ^{[1
]}

机构：

[1] Jilin Agr Univ, Coll Chinese Med Mat, Changchun 130118, Peoples R China

[2] Jilin Univ, Sch Pharmaceut Sci, Changchun 130021, Peoples R China

来源：

MOLECULES | 2022年 / 27卷 / 23期

关键词：

Oviductus Ranae; natural product; inflammatory; 1-Methylhydantoin; trans-cinnamic acid; ACID; DERIVATIVES; INFLAMMATION; ANTAGONISTS; INHIBITION; DISCOVERY; MOLECULES; ESTERS;

D O I：

10.3390/molecules27238481

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study, 1-methylhydantoin cinnamic imides were synthesized from 1-methylhydantoin and trans-cinnamic acid, and their anti-inflammatory activity was investigated. The anti-inflammatory activity in vitro was evaluated by measuring the contents of NO, TNF-alpha and IL-1 beta in the supernatant of RAW264.7 cells stimulated by LPS. The cytotoxicity of 1-methylhydantoin cinnamoyl imides on RAW264.7 cells was detected using the CCK-8 method. The results showed that compounds 2 and 4 can significantly inhibit the release of NO and reduce the secretion of TNF-alpha and IL-1 beta. Compound 3 inhibited the production of TNF-alpha. The inhibition rate of COX was evaluated in vitro. The in vivo anti-inflammatory activities of the five compounds were evaluated by establishing an animal model of xylene ear swelling. The results showed that 1-methylhydantoin cinnamic imides could alleviate xylene-induced ear edema in mice in a dose-dependent manner. Among them, the effect of compound 5 was the most significant. Under the action of high dosage, its ear swelling inhibition rate was as high as 52.08%.

引用

页数：12

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