Association of p53 Arg72Pro polymorphism with gastric cancer: a meta-analysis

被引：14

作者：

Tang, Wenru ^{[1
,2
]}

Zhou, Xuhong ^{[3
]}

Nie, Shengjie ^{[4
]}

Yang, Zhi ^{[4
]}

Zhu, Hui ^{[2
]}

Wu, Xiaoming ^{[2
]}

Zhao, Ruoping ^{[1
]}

Luo, Ying ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming, Peoples R China

[2] Kunming Univ Sci & Technol, Fac Med, Lab Mol Genet Aging & Tumor, Kunming 650500, Yunnan, Peoples R China

[3] Yunnan Acad Agr Sci, Flower Res Inst, Kunming, Peoples R China

[4] Kunming Med Univ, Kunming, Peoples R China

来源：

BIOMARKERS | 2012年 / 17卷 / 07期

基金：

美国国家科学基金会;

关键词：

p53; meta-analysis; gastric cancer; CODON-72; POLYMORPHISM; GENETIC-POLYMORPHISM; STOMACH-CANCER; FREE SURVIVAL; RISK; MUTATIONS; VARIANTS; PATHOLOGY; ARGININE; CARDIA;

D O I：

10.3109/1354750X.2012.704646

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Background: p53 tumor suppressor gene Arg72Pro polymorphism has been associated with gastric cancer. However, results were inconsistent. We performed this meta-analysis to estimate the association between p53 Arg72Pro polymorphism and gastric cancer. Methods: An electronic search of PubMed was conducted to select studies. Studies containing available genotype frequencies of Arg72Pro were chosen, and the association was assess by pooled odds ratio (ORs) with 95% confidence interval (CIs). Results: The meta-analysis suggested that the p53 Arg72Pro was associated with the gastric cancer risk (Additive model: OR = 1.149, 95% CI = 1.045-1.263, p = 0.004; Dominant model: OR = 1.18, 95% CI = 1.049-1.328, p = 0.006; Recessive model: OR = 1.202, 95% CI = 1.013-1.427, p = 0.035) in Asian subgroup. Conclusion: This meta-analysis suggests that p53 Arg72Pro polymorphism is associated with increased risk of gastric cancer in Asians.

引用

页码：597 / 603

页数：7

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