Supragastric belching in Japan: lower prevalence and relevance for management of gastroesophageal reflux disease compared to United Kingdom

被引：6

作者：

Sawada, Akinari ^{[1
,2
]}

Itami, Hideaki ^{[3
]}

Nakagawa, Kenichiro ^{[3
]}

Hirano, Shinji ^{[2
]}

Kitamura, Hiroyuki ^{[2
]}

Nakata, Rieko ^{[2
]}

Takashima, Shingo ^{[2
]}

Abe, Yasuaki ^{[3
]}

Saito, Masahiro ^{[3
]}

Yazaki, Etsuro ^{[1
]}

Kawamura, Osamu ^{[4
]}

Tanaka, Fumio ^{[2
]}

Takeuchi, Toshihisa ^{[5
]}

Koike, Tomoyuki ^{[3
]}

Masamune, Atsushi ^{[3
]}

Fujiwara, Yasuhiro ^{[2
]}

Higuchi, Kazuhide ^{[5
]}

Sifrim, Daniel ^{[1
]}

机构：

[1] Queen Mary Univ London, Upper GI Physiol Unit Royal London Hosp, Barts & London Sch Med & Dent, Wingate Inst Neurogastroenterol, 26 Ashfield St, London E1 2AJ, England

[2] Osaka City Univ, Dept Gastroenterol, Grad Sch Med, Osaka, Japan

[3] Tohoku Univ, Div Gastroenterol, Grad Sch Med, Sendai, Miyagi, Japan

[4] Kamimoku SPA Hosp, Dept Gastroenterol, Minakami, Japan

[5] Osaka Med Coll, Dept Internal Med 2, Takatsuki, Osaka, Japan

来源：

JOURNAL OF GASTROENTEROLOGY | 2020年 / 55卷 / 11期

关键词：

Supragastric belching; Gastroesophageal reflux disease; Impedance-pH monitoring; Cross-cultural study; ESOPHAGEAL PH; SYMPTOM ANALYSIS; ASSOCIATION; ACID;

D O I：

10.1007/s00535-020-01720-9

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background Supragastric belching (SGB) may play a role in the pathophysiology of proton pump inhibitors (PPIs)-refractoriness in gastroesophageal reflux disease (GERD). SGB may be present in up to 40% of reflux symptoms in PPI-refractory GERD. Most reports on SGB have come from Western countries, and little is known about the prevalence and relevance of SGB in Asian refractory GERD patients. This study aimed at comparing the role of SGB in GERD patients in Japan and the UK. Methods We re-analyzed impedance-pH monitoring tracings from patients who were referred to tertiary centers in Japan and the UK due to PPI-refractory reflux symptoms. The prevalence of excessive SGB and the impact of SGB on reflux symptoms were compared between the two countries. Results Impedance-pH tracings from124 Japanese and 83 British patients were re-analyzed. Japanese patients were significantly younger and had smaller body mass index than the British (P < 0.001). Japanese patients had significantly lower prevalence of excessive SGB (18.5%) than the UK (36.1%) irrespective of reflux phenotype (P = 0.006). Logistic regression analysis showed that the geographical/cultural difference was the only factor associated with the different prevalence of SGB (odds ratio; 2.91, 95% CI 1.09-7.73,P = 0.032). SGB were related to typical reflux symptoms very rarely in Japan [0% (0-4.9)] compared to the UK [35% (0-54.1)] (P = 0.071). Conclusions The prevalence of SGB and their impact on reflux symptoms is significantly lower in Japan compared to the UK. The difference is not related to reflux parameters but might come from ethnic/cultural factors to be further characterized.

引用

页码：1046 / 1053

页数：8

共 32 条

[1] Most Patients With Gastroesophageal Reflux Disease Who Failed Proton Pump Inhibitor Therapy Also Have Functional Esophageal Disorders [J].