Paradoxical roles of the immune system during cancer development

被引：1779
作者：
de Visser, KE
Eichten, A
Coussens, LM
机构：
[1] Univ Calif San Francisco, Canc Res Inst, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA
[3] Netherlands Canc Inst, Dept Mol Biol, NL-1066 CX Amsterdam, Netherlands
[4] Univ Calif San Francisco, Ctr Comprehens Canc, San Francisco, CA 94143 USA
来源：
NATURE REVIEWS CANCER | 2006年 / 6卷 / 01期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nrc1782
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The main function of the mammalian immune system is to monitor tissue homeostasis, to protect against invading or infectious pathogens and to eliminate damaged cells. Therefore, it is surprising that cancer occurs with such a high frequency in humans. Recent insights that have been gained from clinical studies and experimental mouse models of carcinogenesis expand our understanding of the complex relationship between immune cells and developing tumours. Here, we examine the paradoxical role of adaptive and innate leukocytes as crucial regulators of cancer development and highlight recent insights that have been gained by manipulating immune responses in mouse models of de novo and spontaneous tumorigenesis.
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收藏
页码：24 / 37
页数：14
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