Cell-mediated immune responses to MUC1 fusion protein coupled to mannan

被引：136

作者：

Apostolopoulos, V ^{[1
]}

Pietersz, GA ^{[1
]}

McKenzie, IFC ^{[1
]}

机构：

[1] AUSTIN RES INST, HEIDELBERG, VIC 3084, AUSTRALIA

来源：

VACCINE | 1996年 / 14卷 / 09期

关键词：

mucin; cytotoxic T cells; mannan; cancer; immunology; MUC1;

D O I：

10.1016/0264-410X(95)00258-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The immunotherapy of cancer requires the definition of a suitable target for and the induction of a CD8(+) cytoxic lymphocyte reaction. In breast cancer, particularly mucins (MUCl) of the variable number of tandem repeat sequence may be a suitable target but there has been a problem in inducing a cytotoxic response. MUCl peptides, conjugated to carriers (keyhole-limpet hemocyanin or diphtheria toxoid) induce a humoral response and give poor tumor protection in mice and there is little cellular immunity. However, when MUCl fusion protein is conjugated to mannan under oxidizing conditions, a cellular immune response in induced, with significant tumor protection, cytotoxic T lymphocytes and little antibody. The procedure may also be useful for other antigens. Copyright (C) 1996 Elsevier Science Ltd.

引用

页码：930 / 938

页数：9

共 41 条

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