Primordial emergence of the recombination activating gene 1 (RAG1): Sequence of the complete shark gene indicates homology to microbial integrases

被引:103
作者
Bernstein, RM [1 ]
Schluter, SF [1 ]
Bernstein, H [1 ]
Marchalonis, JJ [1 ]
机构
[1] UNIV ARIZONA, COLL MED, DEPT MICROBIOL & IMMUNOL, TUCSON, AZ 85724 USA
关键词
D O I
10.1073/pnas.93.18.9454
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The rearrangement of antibody and T-cell receptor gene segments is indispensable to the vertebrate immune response. All extant jawed vertebrates can rearrange these gene segments. This ability is conferred by the recombination activating genes I and II (RAG I and RAG II). To elucidate their origin and function, the cDNA encoding RAG I from a member of the most ancient class of extant gnathostomes, the Carcharhine sharks, was characterized. Homology domains identified within shark RAG I prompted sequence comparison analyses that suggested similarity of the RAG I and II genes, respectively, to the integrase family genes and integration host factor genes of the bacterial site-specific recombination system. Thus, the apparent explosive evolution (or ''big bang'') of the ancestral immune system may have been initiated by a transfer of microbial site-specific recombinases.
引用
收藏
页码:9454 / 9459
页数:6
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