Short-circuiting microtubule plus and minus end proteins in spindle positioning

被引：0

作者：

Rogers, Stephen L. ^{[1
]}

机构：

[1] Univ N Carolina, Dept Biol, Chapel Hill, NC 28223 USA

来源：

EMBO JOURNAL | 2014年 / 33卷 / 02期

关键词：

GAMMA-TUBULIN COMPLEX; IN-VIVO; NUCLEATION; DYNAMICS; YEAST;

D O I：

10.1002/embj.201387341

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Proteins residing at the plus and minus ends of microtubules have been thought not to communicate with each other, but recent findings on bona fide nucleation factors also regulating microtubule dynamics have challenged this notion. New work by Bouissou et al () in The EMBO Journal now reveals that interplay between the nucleation factor gamma-TuRC and the plus-end tracking protein EB1 controls mitotic spindle positioning by affecting the stability and dynamics of astral microtubules.

引用

页码：96 / 98

页数：3

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