Vascular Impairment in Alzheimer's Disease: The Role of Obstructive Sleep Apnea

被引:59
作者
Buratti, Laura [1 ]
Viticchi, Giovanna [1 ]
Falsetti, Lorenzo [2 ]
Cagnetti, Claudia [1 ]
Luzzi, Simona [1 ]
Bartolini, Marco [1 ]
Provinciali, Leandro [1 ]
Silvestrini, Mauro [1 ]
机构
[1] Marche Polytech Univ, Neurol Clin, I-60020 Ancona, Italy
[2] Osped Riuniti Ancona, Ancona, Italy
关键词
Alzheimer's disease; carotid atherosclerosis; cerebral hemodynamics; obstructive sleep apnea; ultrasound; MILD COGNITIVE IMPAIRMENT; INTIMA-MEDIA THICKNESS; CEREBRAL HEMODYNAMICS; RISK-FACTORS; CEREBROVASCULAR REACTIVITY; CAROTID ATHEROSCLEROSIS; STROKE; DECLINE; HYPOXIA; PERFORMANCE;
D O I
10.3233/JAD-131046
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Epidemiological studies have suggested a pathophysiological link between obstructive sleep apnea syndrome (OSAS) and Alzheimer's disease (AD). The mechanism by which sleep disturbance can affect cognitive impairment is not clear. The aim of this study was to investigate whether AD patients with OSAS have an impairment in cerebrovascular disease markers. We included 69 patients without OSAS and 93 patients with OSAS. They underwent an ultrasonographic assessment of common carotid arteries intima-media thickness (IMT) and carotid plaque index. Cerebrovascular reactivity to hypercapnia in the middle cerebral arteries was calculated with the Breath-Holding Index (BHI). Pathological values of IMT and BHI were significantly associated with the presence of OSAS (IMT > 1.0 mm: OR 2.98, 95% CI: 1.37-6.46; p < 0.05; BHI < 0.69: OR 5.25, 95% CI: 2.35-11.74; p < 0.05, multivariate adjusted analysis). Furthermore, the extent of cerebrovascular impairment was correlated with the severity of OSAS. The finding of alterations of cerebral vessel functional and anatomic status in AD patients with OSAS suggests the potential for effective treatment for sleep-related disturbances in a subgroup of AD patients.
引用
收藏
页码:445 / 453
页数:9
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