Rheumatoid arthritis: a view of the current genetic landscape

被引：55

作者：

Coenen, M. J. H. ^{[2
]}

Gregersen, P. K. ^{[1
]}

机构：

[1] N Shore Long Isl Jewish Hlth Syst, Feinstein Inst Med Res, Robert S Boas Ctr Genom & Human Genet, Manhasset, NY 11030 USA

[2] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, NL-6525 ED Nijmegen, Netherlands

来源：

GENES AND IMMUNITY | 2009年 / 10卷 / 02期

关键词：

Rheumatoid arthritis; polymorphism; genome-wide association; LYMPHOID TYROSINE PHOSPHATASE; SYSTEMIC-LUPUS-ERYTHEMATOSUS; GENOME-WIDE ASSOCIATION; NF-KAPPA-B; JUVENILE IDIOPATHIC ARTHRITIS; SHARED EPITOPE; PTPN22; GENE; COPY-NUMBER; 620W ALLELE; PEPTIDYLARGININE DEIMINASE-4;

D O I：

10.1038/gene.2008.77

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The field of genetics and autoimmune diseases is undergoing a rapid and unprecedented expansion with new genetic findings being reported at an astounding pace. It is now clear that multiple genes contribute to each of the major autoimmune disorders, with significant genetic overlaps among them. Rheumatoid arthritis (RA) is no exception to this, and emerging data are beginning to reveal the outlines of new diagnostic subgroups, complex overlapping relationships with other autoimmune disorders and potential new targets for therapy. This review describes the evolving genetic landscape of RA, with the full knowledge that our current view is far from complete. However, with the first round of genome-wide association scans now completed, it is reasonable to begin to take stock of the direction in which the major common genetic risk factors are leading us.

引用

页码：101 / 111

页数：11

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