Diffuser-aided time-domain diffuse optical imaging

We present the first experimental results of time-resolved diffuser-aided diffuse optical imaging (DADOI) method in this letter. A self-manufactured diffuser plate was inserted between the optode and the surface of a scattering medium. The diffuser was utilized to enhance multiple scattering that destroys image information for baseline measurement of turbid medium. Therefore, the abnormality can be detected with the modified optical density calculation. The time-domain DADOI method can provide better imaging contrast and more simply imaging than the conventional DOT measurement. Besides, it also reveals rich depth information with temporal responses. Therefore, the DADOI offers a great potential to detect the breast tumor and chemotherapy monitoring in clinical diagnosis.