Two Cu(II) and Co(II)-based Coordination Polymers Based on the N,S-donor Ligand: Crystal Structures and Anticancer Activity Evaluation

Two new Cu(II) and Co(II)-based coordination polymers with the chemical formulae of {Cu(L)(2)]center dot DMF}(n) (1) and {[Co(L)(2)]center dot 2DMF}(n) (2) have been successfully constructed from a pyridine-substituted N-heterocyclic thioamide ligand, namely [3,4'-bipyridine]-2'-thiol (HL). Complex 1 is composed of two identical coordination networks with dia topology interpenetrating into each other, and shows 1-D microporous channels along the a axis. Complex 2 is assembled by 2-D square-grid layers stacked in an eclipsed fashion to give 1-D large square channels along the b axis. CCK-8 was used for the detection of cancer cells. Results indicated that compound 1 exhibited stronger anti-cancer activity than compound 2 on the H1650 cancer cells. The Annexin V-FITC/PI was recommended for cancer cell apoptosis, and the western blot was applied for the detection of PI3K/AKT pathway activation.