Unfolded Protein Response in Lung Health and Disease

被引：28

作者：

Barabutis, Nektarios ^{[1
]}

机构：

[1] Univ Louisiana, Coll Pharm, Sch Basic Pharmaceut & Toxicol Sci, Monroe, LA 71209 USA

来源：

FRONTIERS IN MEDICINE | 2020年 / 7卷

基金：

美国国家卫生研究院;

关键词：

endothelial dysfunction; ER stress; P53; inflammation; vasculature; ENDOPLASMIC-RETICULUM-STRESS; ENDOTHELIAL BARRIER FUNCTION; HORMONE-RELEASING-HORMONE; ER STRESS; P53; ACTIVATION; TARGET; DEFICIENCY; FIBROSIS; SENSOR;

D O I：

10.3389/fmed.2020.00344

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The unfolded protein response (UPR) is a complex element, destined to protect the cells against a diverse variety of extracellular and intracellular challenges. UPR activation devises highly efficient responses to counteract cellular threats. If those activities fail, it will dictate cellular execution. The current work focuses on the role of UPR in pulmonary function, by immersing into the highly interrelated network that operates toward the endothelial barrier function. A highly sophisticated UPR manipulation shall reveal new therapeutic possibilities against inflammatory lung disease, such as acute lung injury and acute respiratory distress syndrome.

引用

页数：6

共 66 条

[1] Unfolded protein response regulates P53 expression in the pulmonary endothelium [J].

Akhter, Mohammad S. ;

Uddin, Mohammad A. ;

Barabutis, Nektarios .

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2019, 33 (10)

[2] Secretion of the endoplasmic reticulum stress protein, GRP78, into the BALF is increased in cigarette smokers [J].

Aksoy, Mark O. ;

Kim, Victor ;

Cornwell, William D. ;

Rogers, Thomas J. ;

Kosmider, Beata ;

Bahmed, Karim ;

Barrero, Carlos ;

Merali, Salim ;

Shetty, Neena ;

Kelsen, Steven G. .

RESPIRATORY RESEARCH, 2017, 18

[3] Regulation of PERK expression by FOXO3: a vulnerability of drug-resistant cancer cells [J].

Alasiri, Glowi ;

Jiramongkol, Yannasittha ;

Zona, Stefania ;

Fan, Lavender Y. N. ;

Mahmud, Zimam ;

Gong, Gyungyub ;

Lee, Hee Jin ;

Lam, Eric W-F .

ONCOGENE, 2019, 38 (36) :6382-6398

[4] Endoplasmic Reticulum Stress Activates Unfolded Protein Response Signaling and Mediates Inflammation, Obesity, and Cardiac Dysfunction: Therapeutic and Molecular Approach [J].

Amen, Omar Mohammed ;

Sarker, Satyajit D. ;

Ghildyal, Reena ;

Arya, Aditya .

FRONTIERS IN PHARMACOLOGY, 2019, 10

[5]

[Anonymous], 2016, BIOCH PHARM, DOI DOI 10.1016/J.BCP.2016.04.008

[6] Involvement of Endoplasmic Reticulum Stress in Myofibroblastic Differentiation of Lung Fibroblasts [J].

Baek, Hyun Ah ;

Kim, Do Sung ;

Park, Ho Sung ;

Jang, Kyu Yun ;

Kang, Myoung Jae ;

Lee, Dong Geun ;

Moon, Woo Sung ;

Chae, Han Jung ;

Chung, Myoung Ja .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2012, 46 (06) :731-739

[7] P53 in RhoA regulation [J].

Barabutis, Nektarios .

CYTOSKELETON, 2020, 77 (5-6) :197-201

[8] Growth hormone releasing hormone in the unfolded protein response context [J].

Barabutis, Nektarios .

ENDOCRINE, 2020, 67 (02) :291-293

[9] Heat shock protein 90 inhibition in the inflamed lungs [J].

Barabutis, Nektarios .

CELL STRESS & CHAPERONES, 2020, 25 (02) :195-197

[10] Unfolded Protein Response in Acute Respiratory Distress Syndrome [J].

Barabutis, Nektarios .

LUNG, 2019, 197 (06) :827-828

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