It's complicated: The relationship between sleep and Alzheimer's disease in humans

被引：96
作者：
Lucey, Brendan P. [1 ,2 ]
机构：
[1] Washington Univ, Dept Neurol, Sch Med, Campus Box 8111,660 South Euclid Ave, St Louis, MO 63110 USA
[2] Washington Univ, Hope Ctr Neurol Disorders, Sch Med, St Louis, MO 63110 USA
来源：
NEUROBIOLOGY OF DISEASE | 2020年 / 144卷
基金：
美国国家卫生研究院;
关键词：
Sleep; Alzheimer's disease; Amyloid-beta; Tau; FLUID AMYLOID-BETA; MILD COGNITIVE IMPAIRMENT; PERIODIC LIMB MOVEMENTS; SELF-REPORTED SLEEP; CEREBROSPINAL-FLUID; TAU-PROTEIN; OLDER PERSONS; RISK-FACTORS; POOR SLEEP; PATHOLOGY;
D O I：
10.1016/j.nbd.2020.105031
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by an asymptomatic period of amyloid-beta (A beta) deposition as insoluble extracellular plaque, intracellular tau aggregation, neuronal and synaptic loss, and subsequent cognitive dysfunction and dementia. A growing public health crisis, the worldwide prevalence of AD is expected to rise from 46.8 million individuals affected in 2015 to 131.5 million in 2050. Sleep disturbances have been associated with increased future risk of AD. A bi-directional relationship is hypothesized between sleep and AD with sleep disturbances as either markers for AD pathology and/or a mechanism mediating increased risk of AD. In this review, the evidence in humans supporting this complex relationship between sleep and AD will be discussed as well as the therapeutic potential and challenges of treating sleep disturbances to prevent or delay the onset of AD.
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页数：8
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