A cerebrospinal fluid protein associated with moyamoya disease: Report of three cases

被引：13

作者：

Hojo, M ^{[1
]}

Hoshimaru, M ^{[1
]}

Miyamoto, S ^{[1
]}

Taki, W ^{[1
]}

Kikuchi, H ^{[1
]}

Hashimoto, N ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Neurosurg, Sakyo Ku, Kyoto 6068507, Japan

来源：

NEUROSURGERY | 1999年 / 45卷 / 01期

关键词：

cerebrospinal fluid; moyamoya disease; two-dimensional polyacrylamide gel; electrophoresis;

D O I：

10.1097/00006123-199907000-00040

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

OBJECTIVE: The pathogenesis of moyamoya disease is unknown. The purpose of this study was to detect proteins associated with the pathogenesis of moyamoya disease. CLINICAL PRESENTATION: Cerebrospinal fluid (CSF) samples from three patients with moyamoya disease and four control patients who had cervical lesions but no intracranial lesion were studied. INTERVENTION: CSF proteins separated by two-dimensional polyacrylamide gel electrophoresis were analyzed with the SWISS-2DPAGE and SWISS-PROT databases. In the CSF samples from all three patients with moyamoya disease, a polypeptide spot (M-r = 12,000, pI = 5.35) was observed. This spot was not evident in samples from the four control patients and has not been reported in the SWISS-2DPACE and SWISS-PROT databases. CONCLUSION: A CSF protein, which is possibly novel and associated with moyamoya disease, has been detected. The analysis of CSF by two-dimensional polyacrylamide gel electrophoresis may reveal a clue by which the molecular mechanism of moyamoya disease may be elucidated.

引用

页码：170 / 173

页数：4

共 39 条

[1] KINETICS OF I-125 PDGF BINDING AND DOWN-REGULATION OF PDGF RECEPTOR IN ARTERIAL SMOOTH-MUSCLE CELLS DERIVED FROM PATIENTS WITH MOYAMOYA DISEASE [J].

AOYAGI, M ;

FUKAI, N ;

MATSUSHIMA, Y ;

YAMAMOTO, M ;

YAMAMOTO, K .

JOURNAL OF CELLULAR PHYSIOLOGY, 1993, 154 (02) :281-288

[2] ALTERED CELLULAR-RESPONSES TO SERUM MITOGENS, INCLUDING PLATELET-DERIVED GROWTH-FACTOR, IN CULTURED SMOOTH-MUSCLE CELLS DERIVED FROM ARTERIES OF PATIENTS WITH MOYAMOYA DISEASE [J].

AOYAGI, M ;

FUKAI, N ;

SAKAMOTO, H ;

SHINKAI, T ;

MATSUSHIMA, Y ;

YAMAMOTO, M ;

YAMAMOTO, K .

JOURNAL OF CELLULAR PHYSIOLOGY, 1991, 147 (02) :191-198

[3] HUMAN-LEUKOCYTE ANTIGEN IN PATIENTS WITH MOYAMOYA DISEASE [J].

AOYAGI, M ;

OGAMI, K ;

MATSUSHIMA, Y ;

SHIKATA, M ;

YAMAMOTO, M ;

YAMAMOTO, K .

STROKE, 1995, 26 (03) :415-417

[4] SWISS-2DPAGE - A DATABASE OF 2-DIMENSIONAL GEL-ELECTROPHORESIS IMAGES [J].

APPEL, RD ;

SANCHEZ, JC ;

BAIROCH, A ;

GOLAZ, O ;

MIU, M ;

VARGAS, JR ;

HOCHSTRASSER, DF .

ELECTROPHORESIS, 1993, 14 (11) :1232-1238

[5]

Asai Jun-Ichiro, 1992, Neurologia Medico-Chirurgica, V32, P811, DOI 10.2176/nmc.32.811

[6] A NONLINEAR WIDE-RANGE IMMOBILIZED PH GRADIENT FOR 2-DIMENSIONAL ELECTROPHORESIS AND ITS DEFINITION IN A RELEVANT PH SCALE [J].

BJELLQVIST, B ;

PASQUALI, C ;

RAVIER, F ;

SANCHEZ, JC ;

HOCHSTRASSER, D .

ELECTROPHORESIS, 1993, 14 (12) :1357-1365

[7] Progression of ischaemic stroke and excitotoxic aminoacids [J].

Castillo, J ;

Davalos, A ;

Noya, M .

LANCET, 1997, 349 (9045) :79-83

[8] ABNORMAL PROTEINS IN THE CEREBROSPINAL-FLUID OF PATIENTS WITH CREUTZFELDT-JAKOB DISEASE [J].

HARRINGTON, MG ;

MERRIL, CR ;

ASHER, DM ;

GAJDUSEK, DC .

NEW ENGLAND JOURNAL OF MEDICINE, 1986, 315 (05) :279-383

[9]

Harrington Michael G., 1993, Applied and Theoretical Electrophoresis, V3, P229

[10] Role of transforming growth factor-β1 in the pathogenesis of moyamoya disease [J].

Hojo, M ;

Hoshimaru, M ;

Miyamoto, S ;

Taki, W ;

Nagata, I ;

Asahi, M ;

Matsuura, N ;

Ishizaki, R ;

Kikuchi, H ;

Hashimoto, N .

JOURNAL OF NEUROSURGERY, 1998, 89 (04) :623-629

← 1 2 3 4 →