Synthesis and Biological Activity of N-acyl Anabasine and Cytisine Derivatives with Adamantane, Pyridine and 1,2-Azole Fragments

被引：2

作者：

Mukusheva, Gulim K. ^{[1
]}

Zhasymbekova, Aigerym R. ^{[1
]}

Zhumagalieva, Zharkyn Zh. ^{[1
]}

Seidakhmetova, Roza B. ^{[1
]}

Nurkenov, Oralgazy A. ^{[2
]}

Akishina, Ekaterina A. ^{[3
]}

Petkevich, Sergey K. ^{[3
]}

Dikusar, Evgenij A. ^{[3
]}

Potkin, Vladimir I. ^{[3
]}

机构：

[1] Karaganda Buketov Univ, Chem Fac, Karaganda 100024, Kazakhstan

[2] Inst Organ Synth & Coal Chem Republ Kazakhstan, Karaganda 100008, Kazakhstan

[3] Natl Acad Sci Belarus, Inst Phys Organ Chem, Minsk 220072, BELARUS

来源：

MOLECULES | 2022年 / 27卷 / 21期

关键词：

anabasine; cytisine; amides; quaternary pyridinium salts; isoxazole; isothiazole; pyridine; adamantane; antiviral activity; antimicrobial activity; analgesic activity; (-)-CYTISINE; REACTIVITY; ALKALOIDS;

D O I：

10.3390/molecules27217387

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of N-acyl derivatives of anabasine and cytisine were prepared, to discover novel, natural product-based medicinal agents. All synthesized compounds were tested for antimicrobial, antifungal, antiviral and analgesic activity. The most pronounced antibacterial activity was shown by the compounds with isoxazole fragments, while the adamantane derivatives showed the greatest antiviral effect. It was found that the majority of anabasine derivatives showed significant analgesic activity, reducing the pain response of animals to the irritating effect of acetic acid. The presence of a high level of antimicrobial and antiviral activity in newly synthesized compounds makes it possible to consider them promising for further study of their pharmacological properties.

引用

页数：19

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