Molecular Organization of Small Plasmids Bearing blaTEM-1 and Conferring Resistance to β-Lactams in Haemophilus influenzae

被引：14

作者：

Sondergaard, Annette ^{[1
]}

San Millan, Alvaro ^{[2
,3
]}

Santos-Lopez, Alfonso ^{[2
,3
]}

Nielsen, Signe M. ^{[1
]}

Gonzalez-Zorn, Bruno ^{[2
,3
]}

Norskov-Lauritsen, Niels ^{[1
]}

机构：

[1] Aarhus Univ Hosp, Dept Clin Microbiol, DK-8000 Aarhus, Denmark

[2] Univ Complutense Madrid, Fac Vet, Dept Sanidad Anim, Madrid, Spain

[3] Univ Complutense Madrid, VISAVET, Madrid, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2012年 / 56卷 / 09期

关键词：

CLASSIFICATION; BLA(ROB-1); PB1000;

D O I：

10.1128/AAC.00408-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

TEM-1 is the dominant beta-lactamase of Haemophilus influenzae and can be located on small plasmids. Three distinct plasmids with sizes from 4,304 to 5,646 nucleotides (nt) were characterized: pA1606, pA1209, and pPN223. In addition to TEM-1 and a replication enzyme of the Rep 3 superfamily, pA1606 carries a Tn3 resolvase gene and pA1606 and pA1209 carry an open reading frame (ORE) similar to a plasmid recombination enzyme gene described in Gram-positive bacteria. The plasmids transformed strain Rd to the ampicillin-resistant phenotype.

引用

页码：4958 / 4960

页数：3

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