Effect of permeation enhancers on dynamic mechanical properties of acrylate pressure sensitive adhesives

被引：9

作者：

Khire, Achyut ^{[1
]}

Vavia, Pradeep ^{[1
]}

机构：

[1] Inst Chem Technol, Dept Pharmaceut Sci & Technol, Bombay 400019, Maharashtra, India

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2013年 / 458卷 / 01期

关键词：

Dynamic mechanical analysis (DMA); Permeation enhancer; Transdermal; Pressure sensitive adhesive (PSA); Acrylate; ANALYSIS DMA; THERMAL-ANALYSIS; COATED PELLETS; TRANSITIONS; FILMS; GLASS;

D O I：

10.1016/j.ijpharm.2013.09.037

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Physico-chemical properties of permeation enhancers like molecular weight/size, hydrophobicity/hydrophilicity, co-solvency, etc. are necessary during their selection for pharmaceutical product development. Chemical permeation enhancers modulate the viscoelastic properties of pressure sensitive adhesives. The extent of this modulation depends upon the molecular size and branching of the polymeric chains. The functional nature of this branching additionally changes the peel and tack properties of PSA's. Chemical permeation enhancers alone are not able to modify viscoelastic properties of aqueous based PSA's as compared with their solvent based counterparts. These modulated mechanical aspects need to be maintained throughout development of transdermal patch along with other pharmaceutical aspects like drug release and drug stability. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：141 / 147

页数：7

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