Convergent regulatory evolution and loss of flight in paleognathous birds

被引：172

作者：

Sackton, Timothy B. ^{[1
,2
]}

Grayson, Phil ^{[2
,3
]}

Cloutier, Alison ^{[2
,3
]}

Hu, Zhirui ^{[4
]}

Liu, Jun S. ^{[4
]}

Wheeler, Nicole E. ^{[5
,6
]}

Gardner, Paul P. ^{[5
,7
]}

Clarke, Julia A. ^{[8
]}

Baker, Allan J. ^{[9
,10
]}

Clamp, Michele ^{[1
]}

Edwards, Scott V. ^{[2
,3
]}

机构：

[1] Harvard Univ, Informat Grp, Cambridge, MA 02138 USA

[2] Harvard Univ, Dept Organism & Evolutionary Biol, Cambridge, MA 02138 USA

[3] Harvard Univ, Museum Comparat Zool, Cambridge, MA 02138 USA

[4] Harvard Univ, Dept Stat, Cambridge, MA 02138 USA

[5] Univ Canterbury, Sch Biol Sci, Christchurch, New Zealand

[6] Wellcome Sanger Inst, Ctr Genom Pathogen Surveillance, Wellcome Genome Campus, Cambridge, England

[7] Univ Otago, Dept Biochem, Dunedin, New Zealand

[8] Univ Texas Austin, Jackson Sch Geosci, Austin, TX 78712 USA

[9] Royal Ontario Museum, Dept Nat Hist, Toronto, ON, Canada

[10] Univ Toronto, Dept Ecol & Evolutionary Biol, Toronto, ON, Canada

来源：

SCIENCE | 2019年 / 364卷 / 6435期

基金：

加拿大自然科学与工程研究理事会;

关键词：

BOX GENE TBX5; ANCIENT DNA; PHYLOGENETIC ANALYSIS; COMPARATIVE GENOMICS; PELVIC REDUCTION; READ ALIGNMENT; TREE; TOOL; RECONSTRUCTION; NEUROFIBROMIN;

D O I：

10.1126/science.aat7244

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A core question in evolutionary biology is whether convergent phenotypic evolution is driven by convergent molecular changes in proteins or regulatory regions. We combined phylogenomic, developmental, and epigenomic analysis of 11 new genomes of paleognathous birds, including an extinct moa, to show that convergent evolution of regulatory regions, more so than protein-coding genes, is prevalent among developmental pathways associated with independent losses of flight. A Bayesian analysis of 284,001 conserved noncoding elements, 60,665 of which are corroborated as enhancers by open chromatin states during development, identified 2355 independent accelerations along lineages of flightless paleognaths, with functional consequences for driving gene expression in the developing forelimb. Our results suggest that the genomic landscape associated with morphological convergence in ratites has a substantial shared regulatory component.

引用

页码：74 / +

页数：68

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