Are the neuroprotective effects of exercise training systemically mediated?

被引：87

作者：

Tari, Atefe R. ^{[1
,2
]}

Norevik, Cecilie S. ^{[1
,2
]}

Scrimgeour, Nathan R. ^{[1
]}

Kobro-Flatmoen, Asgeir ^{[3
]}

Storm-Mathisen, Jon ^{[4
]}

Bergersen, Linda H. ^{[5
]}

Wrann, Christiane D. ^{[6
,7
]}

Selbaek, Geir ^{[8
,9
,10
]}

Kivipelto, Miia ^{[11
,12
,13
]}

Moreira, Jose Bianco N. ^{[1
]}

Wisloff, Ulrik ^{[1
]}

机构：

[1] Norwegian Univ Sci & Technol, Dept Circulat & Med Imaging, Cardiac Exercise Res Grp, Trondheim, Norway

[2] St Olavs Hosp, Dept Neurol, Trondheim, Norway

[3] Norwegian Univ Sci & Technol, Kavli Inst Syst Neurosci, Ctr Neural Computat, Egil & Pauline Braathen & Fred Kavli Ctr Cort Mic, Trondheim, Norway

[4] Univ Oslo, Dept Mol Med, Oslo, Norway

[5] Univ Oslo, Dept Oral Biol, Oslo, Norway

[6] Massachusetts Gen Hosp, Boston, MA 02114 USA

[7] Harvard Med Sch, Massachusetts Gen Hosp, Henry & Allison McCance Ctr Brain Hlth, Boston, MA 02115 USA

[8] Vestfold Hosp Trust, Norwegian Natl Advisory Unit Ageing & Hlth, Tonsberg, Norway

[9] Univ Oslo, Inst Hlth & Soc, Fac Med, Oslo, Norway

[10] Innlandet Hosp Trust, Res Ctr Age Related Funct Decline & Dis, Ottestad, Norway

[11] Karolinska Inst, Ctr Alzheimer Res, Div Clin Geriatr, Stockholm, Sweden

[12] Univ Eastern Finland, Inst Clin Med, Dept Neurol, Kuopio, Finland

[13] Imperial Coll London, Sch Publ Hlth, Age & Epidemiol Res Unit, London, England

来源：

PROGRESS IN CARDIOVASCULAR DISEASES | 2019年 / 62卷 / 02期

关键词：

Physical activity; Cardiorespiratory fitness; Alzheimer's disease; Dementia; Exercise-induced blood-borne factors; GROWTH-FACTOR-I; ENTORHINAL CORTEX NEURONS; VASCULAR RISK-FACTORS; ALZHEIMERS-DISEASE; SYNAPTIC PLASTICITY; PHYSICAL-ACTIVITY; CATHEPSIN-B; CARDIORESPIRATORY FITNESS; COGNITIVE IMPAIRMENT; AEROBIC EXERCISE;

D O I：

10.1016/j.pcad.2019.02.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To date there is no cure available for dementia, and the field calls for novel therapeutic targets. A rapidly growing body of literature suggests that regular endurance training and high cardiorespiratory fitness attenuate cognitive impairment and reduce dementia risk. Such benefits have recently been linked to systemic neurotrophic factors induced by exercise. These circulating biomolecules may cross the blood-brain barrier and potentially protect against neurodegenerative disorders such as Alzheimer's disease. Identifying exercise-induced systemic neurotrophic factors with beneficial effects on the brain may lead to novel molecular targets for maintaining cognitive function and preventing neurodegeneration. Here we review the recent literature on potential systemic mediators of neuroprotection induced by exercise. We focus on the body of translational research in the field, integrating knowledge from the molecular level, animal models, clinical and epidemiological studies. Taken together, the current literature provides initial evidence that exercise-induced, blood-borne biomolecules, such as BDNF and FNDC5/irisin, may be powerful agents mediating the benefits of exercise on cognitive function and may form the basis for new therapeutic strategies to better prevent and treat dementia. (C) 2019 The Author. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页码：94 / 101

页数：8

共 148 条

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