Plasma klotho levels decrease in both anorexia nervosa and obesity

被引：52

作者：

Amitani, Marie ^{[1
]}

Asakawa, Akihiro ^{[1
]}

Amitani, Haruka ^{[1
]}

Kaimoto, Kaori ^{[1
]}

Sameshima, Nanami ^{[1
]}

Koyama, Ken Ichiro ^{[1
]}

Haruta, Izumi ^{[1
]}

Tsai, Minglun ^{[1
]}

Nakahara, Toshihiro ^{[1
]}

Ushikai, Miharu ^{[1
]}

Cheng, Kai-chun ^{[1
]}

Hamada, Satoshi ^{[1
]}

Inui, Akio ^{[1
]}

机构：

[1] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Psychosomat Internal Med, Kagoshima 890, Japan

来源：

NUTRITION | 2013年 / 29卷 / 09期

关键词：

Klotho; Adiponectin; Aging; Body mass index; Restricting-type anorexia nervosa; Obesity; ADIPONECTIN MULTIMERS; MORTALITY; GENE; UNDERWEIGHT; OVERWEIGHT;

D O I：

10.1016/j.nut.2013.02.005

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Objective: The aim of this study was to examine the associations of klotho with body mass index (BMI) in patients with restricting-type anorexia nervosa (r-AN) and obesity. Method: We examined plasma klotho as well as adiponectin and its isoform levels in comparison in 11 obese patients, 12 r-AN patients, and 11 control participants. Results: Plasma klotho levels were markedly lower in the obesity and r-AN groups than in the control group. Moreover, plasma klotho levels increased significantly after the recovery of BMI in r-AN patients. Total and high-molecular-weight adiponectin levels were significantly decreased only in obesity. There was no relationship between klotho and total adiponectin levels or klotho and respective adiponectin isoform levels in the entire study population. Conclusions: These results suggest that klotho may reflect normal nutritional state, and that the decrease of klotho in r-AN and obesity may underlie the deteriorating processes of these disorders. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：1106 / 1109

页数：4

共 19 条

[1] The role of adiponectin multimers in anorexia nervosa [J].

Amitani, Haruka ;

Asakawa, Akihiro ;

Ogiso, Kazuma ;

Nakahara, Toshihiro ;

Ushikai, Miharu ;

Haruta, Izumi ;

Koyama, Ken-Ichiro ;

Amitani, Marie ;

Cheng, Kai-chun ;

Inui, Akio .

NUTRITION, 2013, 29 (01) :203-206

[2] Klotho protein promotes adipocyte differentiation [J].

Chihara, Yukana ;

Rakugi, Hiromi ;

Ishikawa, Kazuhiko ;

Ikushima, Masashi ;

Maekawa, Yoshihiro ;

Ohta, Junsuke ;

Kida, Iwao ;

Ogihara, Toshio .

ENDOCRINOLOGY, 2006, 147 (08) :3835-3842

[3] A novel ELISA system for selective measurement of human adiponectin multimers by using proteases [J].

Ebinuma, Hiroyuki ;

Miyazaki, Osamu ;

Yago, Hirokazu ;

Hara, Kazuo ;

Yamauchi, Toshimasa ;

Kadowaki, Takashi .

CLINICA CHIMICA ACTA, 2006, 372 (1-2) :47-53

[4] Excess deaths associated with underweight, overweight, and obesity [J].

Flegal, KM ;

Graubard, BI ;

Williamson, DF ;

Gail, MH .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2005, 293 (15) :1861-1867

[5] Factors predictive of ten-year mortality in severe anorexia nervosa patients [J].

Huas, C. ;

Caille, A. ;

Godart, N. ;

Foulon, C. ;

Pham-Scottez, A. ;

Divac, S. ;

Dechartres, A. ;

Lavoisy, G. ;

Guelfi, J. D. ;

Rouillon, F. ;

Falissard, B. .

ACTA PSYCHIATRICA SCANDINAVICA, 2011, 123 (01) :62-70

[6] Klotho as a regulator of oxidative stress and senescence [J].

Kuro-o, Makoto .

BIOLOGICAL CHEMISTRY, 2008, 389 (03) :233-241

[7] Mutation of the mouse klotho gene leads to a syndrome resembling ageing [J].

Kuroo, M ;

Matsumura, Y ;

Aizawa, H ;

Kawaguchi, H ;

Suga, T ;

Utsugi, T ;

Ohyama, Y ;

Kurabayashi, M ;

Kaname, T ;

Kume, E ;

Iwasaki, H ;

Iida, A ;

ShirakiIida, T ;

Nishikawa, S ;

Nagai, R ;

Nabeshima, Y .

NATURE, 1997, 390 (6655) :45-51

[8] Suppression of aging in mice by the hormone Klotho [J].

Kurosu, H ;

Yamamoto, M ;

Clark, JD ;

Pastor, JV ;

Nandi, A ;

Gurnani, P ;

McGuinness, OP ;

Chikuda, H ;

Yamaguchi, M ;

Kawaguchi, H ;

Shimomura, I ;

Takayama, Y ;

Herz, J ;

Kahn, CR ;

Rosenblatt, KP ;

Kuro-o, M .

SCIENCE, 2005, 309 (5742) :1829-1833

[9] Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein [J].

Matsumura, Y ;

Aizawa, H ;

Shiraki-Iida, T ;

Nagai, R ;

Kuro-o, M ;

Nabeshima, Y .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 242 (03) :626-630

[10] Endocrine Dysregulation in Anorexia Nervosa Update [J].

Miller, K. K. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2011, 96 (10) :2939-2949

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