Nanotechnology-Based Drug Delivery Systems for Targeting, Imaging and Diagnosis of Neurodegenerative Diseases

被引：87

作者：

Pehlivan, Sibel Bozdag ^{[1
]}

机构：

[1] Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, TR-06100 Ankara, Turkey

来源：

PHARMACEUTICAL RESEARCH | 2013年 / 30卷 / 10期

关键词：

blood brain barrier; nano-enabled delivery systems; nanotechnology; neurodegenerative diseases; BLOOD-BRAIN-BARRIER; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; PLGA NANOPARTICLES; ENDOTHELIAL-CELLS; OXIDATIVE STRESS; NERVOUS-SYSTEM; IN-VITRO; TRANSFERRIN; DENDRIMERS;

D O I：

10.1007/s11095-013-1156-7

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Neurodegenerative disorders are becoming prevalent with the increasing age of the general population. A number of difficulties have emerged for the potential treatment of neurodegenerative diseases, as these disorders may be multi systemic in nature. Due to limitations regarding the blood brain barrier (BBB) structure, efflux pumps and metabolic enzyme expression, conventional drug delivery systems do not provide efficient therapy for neurodegenerative disorders. Nanotechnology can offer impressive improvement of the neurodegenerative disease treatment by using bio-engineered systems interacting with biological systems at a molecular level. This review focuses on the nano-enabled system applications for the treatment and diagnosis of neurodegenerative diseases, in particular Alzheimer's, Parkinson's and Prion diseases.

引用

页码：2499 / 2511

页数：13

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