Ciprofloxacin Is Actively Transported across Bronchial Lung Epithelial Cells Using a Calu-3 Air Interface Cell Model

被引：49

作者：

Ong, Hui Xin ^{[1
,2
]}

Traini, Daniela ^{[1
,2
]}

Bebawy, Mary ^{[3
]}

Young, Paul M. ^{[1
,2
]}

机构：

[1] Woolcock Inst Med Res, Sydney, NSW, Australia

[2] Univ Sydney, Sydney Med Sch, Discipline Pharmacol, Sydney, NSW 2006, Australia

[3] Univ Technol Sydney, Grad Sch Hlth, Sch Pharm, Broadway, NSW, Australia

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2013年 / 57卷 / 06期

基金：

澳大利亚研究理事会;

关键词：

RESISTANCE PROTEINS MRP1; FLUOROQUINOLONE CIPROFLOXACIN; PSEUDOMONAS-AERUGINOSA; INTESTINAL SECRETION; DRUG TRANSPORTERS; EXPRESSION; EFFICACY; TISSUE; ACCUMULATION; PENETRATION;

D O I：

10.1128/AAC.00306-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Ciprofloxacin is a well-established broad-spectrum fluoroquinolone antibiotic that penetrates well into the lung tissues; still, the mechanisms of its transepithelial transport are unknown. The contributions of specific transporters, including multidrug efflux transporters, organic cation transporters, and organic anion-transporting polypeptide transporters, to the uptake of ciprofloxacin were investigated in vitro using an air interface bronchial epithelial model. Our results demonstrate that ciprofloxacin is subject to predominantly active influx and a slight efflux component.

引用

页码：2535 / 2540

页数：6

共 44 条

[1] Co-spray-dried mannitol-ciprofloxacin dry powder inhaler formulation for cystic fibrosis and chronic obstructive pulmonary disease [J].

Adi, Handoko ;

Young, Paul M. ;

Chan, Hak-Kim ;

Agus, Helen ;

Traini, Daniela .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2010, 40 (03) :239-247

[2] Systemic Exposure, Tissue Distribution, and Disease Evolution of a High Solubility Ciprofloxacin-Aluminum Complex in a Murine Model of Septicemia Induced by Salmonella enterica Serotype Enteritidis [J].

Andrea Breda, Susana ;

Laura Guzman, Maria ;

Confalonieri, Alejandra ;

Gonzalez, Claudia ;

Sparo, Monica ;

Hilario Manzo, Ruben ;

Sanchez Bruni, Sergio ;

Eugenia Olivera, Maria .

MOLECULAR PHARMACEUTICS, 2013, 10 (02) :598-605

[3] Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions [J].

Bakos, É ;

Evers, R ;

Sinkó, E ;

Váradi, A ;

Borst, P ;

Sarkadi, B .

MOLECULAR PHARMACOLOGY, 2000, 57 (04) :760-768

[4] Tobramycin solution for inhalation reduces sputum Pseudomonas aeruginosa density in bronchiectasis [J].

Barker, AF ;

Couch, L ;

Fiel, SB ;

Gotfried, MH ;

Ilowite, J ;

Meyer, KC ;

O'Donnell, A ;

Sahn, SA ;

Smith, LJ ;

Stewart, JO ;

Abuan, T ;

Tully, H ;

Van Dalfsen, J ;

Wells, CD ;

Quan, J .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2000, 162 (02) :481-485

[5] Drug Transporters in the Lung-Do They Play a Role in the Biopharmaceutics of Inhaled Drugs? [J].

Bosquillon, Cynthia .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2010, 99 (05) :2240-2255

[6] P-Glycoprotein-Mediated Transport of Moxifloxacin in a Calu-3 Lung Epithelial Cell Model [J].

Brillault, Julien ;

De Castro, Whocely Victor ;

Harnois, Thomas ;

Kitzis, Alain ;

Olivier, Jean-Christophe ;

Couet, William .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (04) :1457-1462

[7]

Bur M, 2008, EXPERT OPIN DRUG DEL, V5, P641, DOI [10.1517/17425247.5.6.641, 10.1517/17425247.5.6.641 ]

[8] INCREASED ACCUMULATION OF DRUGS IN A MULTIDRUG RESISTANT CELL-LINE BY ALTERATION OF MEMBRANE BIOPHYSICAL PROPERTIES [J].

CALLAGHAN, R ;

STAFFORD, A ;

EPAND, RM .

BIOCHIMICA ET BIOPHYSICA ACTA, 1993, 1175 (03) :277-282

[9] Fluoroquinolone (ciprofloxacin) secretion by human intestinal epithelial (Caco-2) cells [J].

Cavet, ME ;

West, M ;

Simmons, NL .

BRITISH JOURNAL OF PHARMACOLOGY, 1997, 121 (08) :1567-1578

[10] Transepithelial transport of the fluoroquinolone ciprofloxacin by human airway epithelial Calu-3 cells [J].

Cavet, ME ;

West, M ;

Simmons, NL .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (12) :2693-2698

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