Preparation and in vitro Release Properties of Mercaptopurine Drug-loaded Magnetic Microspheres

被引：2

作者：

Xu Haixing ^{[1
,2
]}

Zhang Yu ^{[1
]}

Niu Xiaoqian ^{[1
]}

Wang Ling ^{[1
]}

Chen Hui ^{[1
]}

Zhang Xi ^{[1
]}

Tang Qiuhan ^{[1
]}

Huang Zhijun ^{[1
,2
]}

Liu Hui ^{[1
]}

Xu Peihu ^{[1
,2
]}

机构：

[1] Wuhan Univ Technol, Sch Chem Engn, Dept Pharmaceut Engn, Wuhan 430070, Peoples R China

[2] Engn Technol Ctr Hubei Tradit Chinese Med Prepara, Wuhan 430070, Peoples R China

来源：

JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION | 2013年 / 28卷 / 06期

关键词：

mercaptoputine; magnetic microspheres; drug loading content; encapsulation efficiency; GELATIN; DELIVERY; MICROPARTICLES; NANOPARTICLES;

D O I：

10.1007/s11595-013-0851-x

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Magnetic Fe3O4 nanoparticles were synthesized by co-precipitation method and the mercaptopurine (MER) drug-loaded magnetic microspheres were obtained through emulsion cross-linking methods. The efficiency of this approach was evaluated in terms of drug loading content (DLC), encapsulation efficiency (EE) and delivery properties in vitro, determined by high performance liquid chromatograph (HPLC). The microspheres showed good DLC values of 11.8%, as well as good EE values of 79.4%. The in vitro drug release study was carried out in phosphate buffer solution (PBS) simulated body fluid, at 37 degrees C with pH=7.4. The release profiles showed an initial fast release rate, which decreased as time progressed and about 84 % had been released after 48 h. The experimental results indicated that the prepared magnetic microspheres may be useful for potential applications of MER for magnetically targeted chemotherapy.

引用

页码：1231 / 1235

页数：5

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