Microneedle-mediated drug delivery for cutaneous diseases

被引：35
作者：
Chen, Jian [1 ]
Ren, Hui [1 ]
Zhou, Pan [2 ]
Zheng, Shuai [2 ]
Du, Bin [3 ]
Liu, Xiaowen [1 ]
Xiao, Fei [1 ]
机构：
[1] Jinan Univ, Clin Translat Ctr Targeted Drug, Sch Med, Dept Pharmacol, Guangzhou, Peoples R China
[2] Jinan Univ, Affiliated Hosp 1, Dept Orthopaed, Guangzhou, Peoples R China
[3] Tongji Univ, Shanghai Matern & Infant Hosp 1, Dept Pathol, Sch Med, Shanghai, Peoples R China
来源：
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | 2022年 / 10卷
基金：
中国国家自然科学基金;
关键词：
drug delivery; microneedle; cutaneous disease; transdermal route; microneedle fabrication; DISSOLVING MICRONEEDLE; TRANSDERMAL DELIVERY; ATOPIC-DERMATITIS; RADIOFREQUENCY DEVICE; SILICON MICRONEEDLES; COATED MICRONEEDLES; DRAWING LITHOGRAPHY; HOLLOW MICRONEEDLES; VACCINE DELIVERY; ACNE SCARS;
D O I：
10.3389/fbioe.2022.1032041
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Microneedles have garnered significant interest as transdermal drug delivery route owing to the advantages of nonselective loading capacity, minimal invasiveness, simple operation, and good biocompatibility. A number of therapeutics can be loaded into microneedles, including hydrophilic and hydrophobic small molecular drugs, and macromolecular drugs (proteins, mRNA, peptides, vaccines) for treatment of miscellaneous diseases. Microneedles feature with special benefits for cutaneous diseases owing to the direct transdermal delivery of therapeutics to the skin. This review mainly introduces microneedles fabricated with different technologies and transdermal delivery of various therapeutics for cutaneous diseases, such as psoriasis, atopic dermatitis, skin and soft tissue infection, superficial tumors, axillary hyperhidrosis, and plantar warts.
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页数：16
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